HIV reservoirs as obstacles and opportunities for an HIV cure

被引：188

作者：

Chun, Tae-Wook ^{[1
]}

Moir, Susan ^{[1
]}

Fauci, Anthony S. ^{[1
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; CD4(+) T-CELLS; BROADLY NEUTRALIZING ANTIBODIES; HISTONE DEACETYLASE INHIBITORS; VIRAL RESERVOIR; LATENT RESERVOIR; HIV-1-INFECTED PATIENTS; ANTIVIRAL THERAPY; EXTENDED PERIODS; RHESUS-MONKEYS;

D O I：

10.1038/ni.3152

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is discontinued, even if plasma viremia has been successfully suppressed for prolonged periods of time. Numerous approaches aimed at eradicating the virus, as well as maintaining its prolonged suppression in the absence of ART, have had little success. A better understanding of the pathophysiologic nature of HIV reservoirs and the impact of various interventions on their persistence is essential for the development of successful therapeutic strategies against HIV or the long-term control of infection. Here, we discuss the persistent HIV reservoir as a barrier to cure as well as the current therapeutic strategies aimed at eliminating or controlling the virus in the absence of ART.

引用

页码：584 / 589

页数：6

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