Portopulmonary hypertension and hepatorenal syndrome. Two faces of the same coin

被引：14

作者：

Zardi, Enrico Maria ^{[1
]}

Zardi, Domenico Maria ^{[2
]}

Giorgi, Chiara ^{[3
]}

Chin, Diana ^{[4
]}

Dobrina, Aldo ^{[5
]}

机构：

[1] Campus Biomed Univ, Internal Med Dept, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[2] Univ Roma La Sapienza, S Andrea Hosp, Intervent Cardiol Dept, Rome, Italy

[3] Osped S Maria Misericordia, Radiol Dept, Urbino, Italy

[4] San Camillo Hosp, Intervent Cardiol Dept, Rome, Italy

[5] Univ Trieste, Dept Physiol & Pathol, Trieste, Italy

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2017年 / 43卷

关键词：

Liver cirrhosis; Portal hypertension; Oesophageal varices; LIVER-TRANSPLANTATION; PORTOSYSTEMIC SHUNTS; CIRRHOSIS; TERLIPRESSIN; TRIAL; HYPONATREMIA; CANDIDATES; FIBROSIS; BOSENTAN; SURVIVAL;

D O I：

10.1016/j.ejim.2017.05.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Portopulmonary hypertension and hepatorenal syndrome are both severe local hypertensive complications of liver cirrhosis and portal hypertension. Both are characterized by vasoconstrictive manifestations regarding pulmonary and renal vascular network, respectively. This review addresses the mechanisms underlying the development of vasoconstriction that leads to local vascular hypertension in the lung and in the kidney with the result of organ dysfunction. Potential therapeutic options are available for the management of these two syndromes as a bridge for liver transplantation; clinical efficacy depends in part on the time and rapidity of intervention and in part on how serious the chain of events is that has triggered the entire vasoconstrictive process. (C) 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

引用

页码：22 / 27

页数：6

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