Inhaled interferons beta and SARS-COV2 infection: a preliminary therapeutic perspective

被引：8

作者：

Cojocaru, Elena ^{[1
]}

Cojocaru, Cristian ^{[2
]}

Antoniu, Sabina Antonela ^{[3
]}

Stafie, Celina Silvia ^{[4
]}

Rajnoveanu, Armand ^{[5
]}

Rajnoveanu, Ruxandra-Mioara ^{[6
]}

机构：

[1] Grigore T Popa Univ Med & Pharm, Morpho Funct Sci Dept 2, Iasi, Romania

[2] Grigore T Popa Univ Med & Pharm, Med Dept 3, 16 Univ St, Iasi 700115, Romania

[3] Grigore T Popa Univ Med & Pharm, Med Dept 2, Iasi, Romania

[4] Grigore T Popa Univ Med & Pharm, Prevent Med & Interdisciplinar Dept, Iasi, Romania

[5] Iuliu Hatieganu Univ Med & Pharm, Occupat Med Dept, Cluj Napoca, Romania

[6] Iuliu Hatieganu Univ Med & Pharm, Palliat Care Dept, Cluj Napoca, Romania

来源：

EXPERT REVIEW OF RESPIRATORY MEDICINE | 2022年 / 16卷 / 03期

关键词：

Interferon; nebulization; SARS-COV2; asthma; COPD; COVID-19; EXPERIMENTAL RHINOVIRUS INFECTION; IFN-BETA; RESPONSES; TRIAL;

D O I：

10.1080/17476348.2022.2008910

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction SARS-COV2 infection represents a therapeutic challenge due to the limited number of effective therapies available and due to the fact that it is not clear which host response in terms of inflammation pattern is the most predictive for an optimal (and rapid) recovery. Interferon beta pathway is impaired in SARS-COV2 infection and this is associated with a bigger disease burden. Exogenous inhaled interferon might be beneficial in this setting. Areas covered Nebulized interferon-beta is currently investigated as a potential therapy for SARS-COV2 because the available data from a phase II study demonstrate that this medication is able to accelerate the recovery from disease. Expert opinion Further clinical studies are needed in order to better document the efficacy of this therapy especially in severe forms of COVID-19, the optimal duration of therapy and if such a medication is appropriate for domiciliary use. Also combined regimens with antivirals or with compounds which are able to enhance the endogenous production of interferon might be of promise.

引用

页码：257 / 261

页数：5

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