Development and Validation of Analytical Method for Sulfonamide Residues in Eggs by Liquid Chromatography Tandem Mass Spectrometry based on the Comission Decision 2002/657/EC

被引：5

作者：

de la Cruz, Marcia N. S. ^{[1
]}

Soares, Renata F. ^{[1
]}

Marques, Anna Sylvia F. ^{[2
]}

de Aquino-Neto, Francisco Radler ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, LADETEC Inst Quim, Ilha Fundao, BR-21941909 Rio De Janeiro, Brazil

[2] Appl Biosyst Brasil, BR-04311000 Sao Paulo, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2011年 / 22卷 / 03期

关键词：

sulfonamides; egg; SPE; LC-MS/MS; SUPERCRITICAL-FLUID EXTRACTION; SOLID-PHASE EXTRACTION; FLUORESCENCE DETECTION; ORGANIC-SOLVENTS; QUANTITATIVE-DETERMINATION; MULTIRESIDUE DETERMINATION; MULTICLASS DETERMINATION; CONFIRMATORY METHOD; HPLC DETERMINATION; VETERINARY DRUGS;

D O I：

10.1590/S0103-50532011000300007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Liquid chromatography-electrospray ionization - tandem mass spectrometry (LC-ESI-MS/MS) was used to simultaneous determination of ten sulfonamide (SAs) residues (sulfacetamide, sulfathiazole, sulfamerazine, sulfamethazine, sulfamethoxypyridazine, sulfamethizole, sulfachloropyridazine, sulfamethoxazole, sulfadimethoxine and sulfaquinoxaline) in eggs. Samples were extracted with acetonitrile and the supernatants were cleaned up by solid phase extraction. After solvent evaporation and reconstitution, aliquots of the final extracts were injected into a LC-ESI-MS/MS in positive mode for all sulfonamides. The validated method resulted in recoveries ranging between 87 and 116% with relative standard deviations between 8.5 and 27.2%, CC alpha between 101.0 and 122.1 ng g(-1), and CC beta between 114.5 and 138.8 ng g(-1). The analytical method, using fortified samples, was validated based on the Commission Decision 2002/657/EC.

引用

页码：454 / 461

页数：8

共 59 条

[21] Cooking effects on sulfonamide residues in chicken thigh muscle
Furusawa, N
Hanabusa, R
[J]. FOOD RESEARCH INTERNATIONAL, 2002, 35 (01) : 37 - 42
[22] Clean and rapid liquid chromatographic technique for monitoring of oxytetracycline and sulphadimicline in milk without use of organic solvents
Furusawa, N
[J]. CHROMATOGRAPHIA, 2003, 57 (5-6) : 317 - 320
[23] Rapid high-performance liquid chromatographic determining technique of sulfamonomethoxine, sulfadimethoxine, and sulfaquinoxaline in eggs without use of organic solvents
Furusawa, N
[J]. ANALYTICA CHIMICA ACTA, 2003, 481 (02) : 255 - 259
[24] Furusawa N, 2002, J AOAC INT, V85, P848
[25] High-performance liquid chromatographic procedure for routine residue monitoring of seven sulfonamides in milk
Furusawa, N
Kishida, K
[J]. FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 2001, 371 (07): : 1031 - 1033
[26] Transference of dietary veterinary drugs into eggs
Furusawa, N
[J]. VETERINARY RESEARCH COMMUNICATIONS, 2001, 25 (08) : 651 - 662
[27] In vitro hepatobiotransformation of sulphadimethoxine in laying hens
Furusawa, N
[J]. JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE, 2001, 48 (03): : 147 - 152
[28] HPLC determination of sulfadimethoxine and its hydroxy metabolites following SPE of edible chicken tissues
Furusawa, N
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2000, 23 (09) : 1413 - 1422
[29] Organic solvents-free technique for determining sulfadimethoxine and its metabolites in chicken meat
Furusawa, Naoto
[J]. JOURNAL OF CHROMATOGRAPHY A, 2007, 1172 (01) : 92 - 95
[30] HPLC determination of sulfadiazine residues in coho salmon (Oncorhynchus kisutch) with confirmation by liquid chromatography with atmospheric pressure chemical ionization mass spectrometry
Gehring, TA
Rushing, LG
Churchwell, MI
Doerge, DR
McErlane, KM
Thompson, HC
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, 44 (10) : 3164 - 3169

← 1 2 3 4 5 6 →