Driving CARs on the Highway to Solid Cancer: Some Considerations on the Adoptive Therapy with CAR T Cells

被引：31

作者：

Abken, Hinrich ^{[1
,2
]}

机构：

[1] Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany

[2] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany

来源：

HUMAN GENE THERAPY | 2017年 / 28卷 / 11期

关键词：

chimeric antigen receptor; adoptive cell therapy; T cell; solid tumor; CHIMERIC ANTIGEN RECEPTORS; I CLINICAL-TRIAL; PHASE-I; ANTITUMOR-ACTIVITY; CD28; COSTIMULATION; RECOMBINANT IMMUNORECEPTORS; ESTABLISHED TUMORS; IMMUNOTHERAPY; EFFICACY; RECOGNITION;

D O I：

10.1089/hum.2017.115

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Adoptive therapy with chimeric antigen receptor (CAR) redirected T cells achieved lasting remissions in hematologic malignancies, even in terminal stages of the disease. Exploring CAR T cell therapy in the treatment of solid tumors has just begun, balancing efficacy versus toxicity in early phase trials. In contrast to leukemia/lymphoma, solid tumors display a tremendously variable biology demanding different strategies to make a T cell attack successful in the long term. This article summarizes current developments, discusses the hurdles, and considers some modifications to improve the CAR T cell therapy in the treatment of solid tumors.

引用

页码：1047 / 1060

页数：14

共 92 条

[71] Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma [J].

Pule, Martin A. ;

Savoldo, Barbara ;

Myers, G. Doug ;

Rossig, Claudia ;

Russell, Heidi V. ;

Dotti, Gianpietro ;

Huls, M. Helen ;

Liu, Enli ;

Gee, Adrian P. ;

Mei, Zhuyong ;

Yvon, Eric ;

Weiss, Heidi L. ;

Liu, Hao ;

Rooney, Cliona M. ;

Heslop, Helen E. ;

Brenner, Malcolm K. .

NATURE MEDICINE, 2008, 14 (11) :1264-1270

[72] Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells [J].

Qasim, Waseem ;

Zhan, Hong ;

Samarasinghe, Sujith ;

Adams, Stuart ;

Amrolia, Persis ;

Stafford, Sian ;

Butler, Katie ;

Rivat, Christine ;

Wright, Gary ;

Somana, Kathy ;

Ghorashian, Sara ;

Pinner, Danielle ;

Ahsan, Gul ;

Gilmour, Kimberly ;

Lucchini, Giovanna ;

Inglott, Sarah ;

Mifsud, William ;

Chiesa, Robert ;

Peggs, Karl S. ;

Chan, Lucas ;

Farzaneh, Farzin ;

Thrasher, Adrian J. ;

Vora, Ajay ;

Pule, Martin ;

Veys, Paul .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (374)

[73] Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits [J].

Roybal, Kole T. ;

Rupp, Levi J. ;

Morsut, Leonardo ;

Walker, Whitney J. ;

McNally, Krista A. ;

Park, Jason S. ;

Lim, Wendell A. .

CELL, 2016, 164 (04) :770-779

[74] T-cell trafficking in the central nervous system [J].

Sallusto, Federica ;

Impellizzieri, Daniela ;

Basso, Camilla ;

Laroni, Alice ;

Uccelli, Antonio ;

Lanzavecchia, Antonio ;

Engelhardt, Britta .

IMMUNOLOGICAL REVIEWS, 2012, 248 :216-227

[75] EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss [J].

Sampson, John H. ;

Choi, Bryan D. ;

Sanchez-Perez, Luis ;

Suryadevara, Carter M. ;

Snyder, David J. ;

Flores, Catherine T. ;

Schmittling, Robert J. ;

Nair, Smita K. ;

Reap, Elizabeth A. ;

Norberg, Pamela K. ;

Herndon, James E., II ;

Kuan, Chien-Tsun ;

Morgan, Richard A. ;

Rosenberg, Steven A. ;

Johnson, Laura A. .

CLINICAL CANCER RESEARCH, 2014, 20 (04) :972-984

[76] Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis [J].

Schietinger, Andrea ;

Philip, Mary ;

Krisnawan, Varintra E. ;

Chiu, Edison Y. ;

Delrow, Jeffrey J. ;

Basom, Ryan S. ;

Lauer, Peter ;

Brockstedt, Dirk G. ;

Knoblaugh, Sue E. ;

Haemmerling, Guenter J. ;

Schell, Todd D. ;

Garbi, Natalio ;

Greenberg, Philip D. .

IMMUNITY, 2016, 45 (02) :389-401

[77] The epigenetic landscape of T cell exhaustion [J].

Sen, Debattama R. ;

Kaminski, James ;

Barnitz, R. Anthony ;

Kurachi, Makoto ;

Gerdemann, Ulrike ;

Yates, Kathleen B. ;

Tsao, Hsiao-Wei ;

Godec, Jernej ;

LaFleur, Martin W. ;

Brown, Flavian D. ;

Tonnerre, Pierre ;

Chung, Raymond T. ;

Tully, Damien C. ;

Allen, Todd M. ;

Frahm, Nicole ;

Lauer, Georg M. ;

Wherry, E. John ;

Yosef, Nir ;

Haining, W. Nicholas .

SCIENCE, 2016, 354 (6316) :1165-1169

[78] Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer [J].

Shrimali, Rajeev K. ;

Yu, Zhiya ;

Theoret, Marc R. ;

Chinnasamy, Dhanalakshmi ;

Restifo, Nicholas P. ;

Rosenberg, Steven A. .

CANCER RESEARCH, 2010, 70 (15) :6171-6180

[79] Survivin Blockade Sensitizes Rhabdomyosarcoma Cells for Lysis by Fetal Acetylcholine Receptor-Redirected T Cells [J].

Simon-Keller, Katja ;

Paschen, Annette ;

Hombach, Andreas A. ;

Stroebel, Philipp ;

Coindre, Jean-Michel ;

Eichmueller, Stefan B. ;

Vincent, Angela ;

Gattenloehner, Stefan ;

Hoppe, Florian ;

Leuschner, Ivo ;

Stegmaier, Sabine ;

Koscielniak, Ewa ;

Leverkus, Martin ;

Altieri, Dario C. ;

Abken, Hinrich ;

Marx, Alexander .

AMERICAN JOURNAL OF PATHOLOGY, 2013, 182 (06) :2121-2131

[80] Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors [J].

Smith, Tyrel T. ;

Moffett, Howell F. ;

Stephan, Sirkka B. ;

Opel, Cary F. ;

Dumigan, Amy G. ;

Jiang, Xiuyun ;

Pillarisetty, Venu G. ;

Pillai, Smitha P. S. ;

Wittrup, K. Dane ;

Stephan, Matthias T. .

JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (06) :2176-2191

← 1 2 3 4 5 6 7 8 9 10 →