Driving CARs on the Highway to Solid Cancer: Some Considerations on the Adoptive Therapy with CAR T Cells

被引：31

作者：

Abken, Hinrich ^{[1
,2
]}

机构：

[1] Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany

[2] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany

来源：

HUMAN GENE THERAPY | 2017年 / 28卷 / 11期

关键词：

chimeric antigen receptor; adoptive cell therapy; T cell; solid tumor; CHIMERIC ANTIGEN RECEPTORS; I CLINICAL-TRIAL; PHASE-I; ANTITUMOR-ACTIVITY; CD28; COSTIMULATION; RECOMBINANT IMMUNORECEPTORS; ESTABLISHED TUMORS; IMMUNOTHERAPY; EFFICACY; RECOGNITION;

D O I：

10.1089/hum.2017.115

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Adoptive therapy with chimeric antigen receptor (CAR) redirected T cells achieved lasting remissions in hematologic malignancies, even in terminal stages of the disease. Exploring CAR T cell therapy in the treatment of solid tumors has just begun, balancing efficacy versus toxicity in early phase trials. In contrast to leukemia/lymphoma, solid tumors display a tremendously variable biology demanding different strategies to make a T cell attack successful in the long term. This article summarizes current developments, discusses the hurdles, and considers some modifications to improve the CAR T cell therapy in the treatment of solid tumors.

引用

页码：1047 / 1060

页数：14

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