New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

被引：81

作者：

Neely, Sarah A. ^{[1
,2
]}

Williamson, Jill M. ^{[1
,2
]}

Klingseisen, Anna ^{[1
,2
]}

Zoupi, Lida ^{[2
,3
]}

Early, Jason J. ^{[1
,2
]}

Williams, Anna ^{[2
,3
]}

Lyons, David A. ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh BioQuarter, Edinburgh, Midlothian, Scotland

[2] Edinburgh BioQuarter, MS Soc Edinburgh Ctr MS Res, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, Ctr Regenerat Med, Inst Regenerat & Repair, Edinburgh BioQuarter, Edinburgh, Midlothian, Scotland

来源：

NATURE NEUROSCIENCE | 2022年 / 25卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GROWTH; REMYELINATION; AXONS;

D O I：

10.1038/s41593-021-01009-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neely et al. investigated the regeneration of different oligodendrocytes after demyelination. They found that newly generated cells exhibit much more proficient remyelination than those that survive demyelination, with implications for MS. Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes generated after demyelination make abundant and correctly targeted sheaths, indicating that they likely also have a better regenerative potential in MS.

引用

页码：415 / +

页数：22

共 32 条

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