Methodological considerations in the study of genetic discrimination - A review

被引：17
作者：
Treloar, S
Taylor, S
Otlowski, M
Barlow-Stewart, K
Stranger, M
Chenoweth, K
机构：
[1] Univ Queensland, Off Publ Policy & Eth, Inst Mol Biosci, Brisbane, Qld, Australia
[2] Univ Queensland, Sch Social Work & Appl Human Sci, Brisbane, Qld, Australia
[3] Queensland Inst Med Res, Brisbane, Qld 4006, Australia
[4] Univ Tasmania, Sch Law, Hobart, Tas, Australia
[5] Royal N Shore Hosp, Ctr Genet Educ, Sydney, NSW, Australia
[6] Queensland Clin Genet Serv, Queensland Hlth, Brisbane, Qld, Australia
来源：
COMMUNITY GENETICS | 2004年 / 7卷 / 04期
关键词：
genetic conditions; genetic discrimination; family history; epidemiology; methodology; study design;
D O I：
10.1159/000082254
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The potential significance and dimensions of genetic discrimination have been described extensively in published literature, but epidemiological and verified case data are limited. Obtaining unbiased data from individuals about discrimination which has been based on erroneous or unjustifiable assumptions about their genetic predispositions poses unique challenges. Through review and discussion of research literature, we identify methodological considerations for collecting valid epidemiological data on genetic discrimination from individuals in the community; in particular, we consider issues which relate to sampling, selection and response. We identify issues to promote sound study design, with particular attention to verification of genetic discrimination, and highlight the importance of clinical and genetic knowledge of complex genotype-phenotype relationships. Copyright © 2004 S. Karger AG, Basel.
引用
收藏
页码：161 / 168
页数：8
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