Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma

被引：22
作者：
Korwar, Arvind M. [2 ]
Bhonsle, Hemangi S. [1 ]
Chougale, Ashok D. [1 ]
Kote, Sachin S. [1 ]
Gawai, Kachru R. [2 ]
Ghole, Vikram S. [2 ]
Koppikar, Chaitanyananda B. [3 ]
Kulkarni, Mahesh J. [1 ]
机构：
[1] CSIR, Natl Chem Lab, Prote Facil, Div Biochem Sci, Pune 411008, Maharashtra, India
[2] Univ Pune, Dept Chem, Pune 411007, Maharashtra, India
[3] Jehangir Hosp & Med Ctr, Pune 411001, Maharashtra, India
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 419卷 / 03期
关键词：
Breast cancer; Advanced glycation end products; RAGE; GLYCATION END-PRODUCTS; OXIDATIVE STRESS; GENE-EXPRESSION; HUMAN-BREAST; ANNEXIN-II; CANCER; RECEPTOR; LIGANDS; CELLS; AMPHOTERIN;
D O I：
10.1016/j.bbrc.2012.02.039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer is associated with increased glycolysis and carbonyl stress. In view of this, AGE modified proteins were identified from clinical breast cancer tissue using 2DE-immunoblot and mass-spectrometry. These proteins were identified to be serotransferrin, fibrinogen gamma chain, glycerol-3-phosphate dehydrogenase, lactate dehydrogenase, annexin II, prohibitin and peroxiredoxin 6, which have established role in cancer. Further, RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB were studied. Role of these AGE modified proteins and RAGE signaling in breast cancer is discussed. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：490 / 494
页数：5
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