Effects of acute and repeated methamphetamine treatment on the ultrasonic vocalizations of postnatal rats

Repeated exposure to cocaine (COC) has been reported to both increase ultrasonic vocalizations (USVs) of postnatal rats and enhance the crying of human infants. The purpose of the present study was to determine whether acute or repeated treatment with another commonly abused psychostimulant, methamphetamine (MAP), would affect the USV production of postnatal rats. In the first experiment, USVs were measured 30 min after rats were given an acute injection of saline or MAR (1, 2, 4, or 8 mg/kg ip) on postnatal day (PD) 10. In the second experiment, rats were exposed to MAP (0, 1, or 4 mg/kg/day ip) on PD 2-8 or PD 2-9. On PD 10, rats were given an acute injection of saline or MAP (I or 4 mg/kg ip) 30 min prior to behavioral assessment. Results showed that acute treatment with MAP (4 or 8 mg/kg) decreased the USVs of rats on PD 10, while repeated exposure to MAP did not affect the USV emissions of rats subsequently treated with saline or MAP. The reason why acute MAP treatment decreased USV production is uncertain, but it is possible that MAP alleviates isolation distress by stimulating reward processes. Alternatively, MAP increases heart rate and blood pressure, so acute treatment with this drug may decrease USV emissions through peripheral physiological mechanisms (i.e., by reducing abdominal compression reactions). (C) 2001 Elsevier Science Inc. All fights reserved.