Scheduling the adjuvant endocrine therapy for early stage breast cancer

被引：2

作者：

Kahruman, Sera ^{[1
]}

Ulusal, Elif ^{[1
]}

Butenko, Sergiy ^{[1
]}

Hicks, Illya V. ^{[2
]}

Diehl, Kathleen M. ^{[3
]}

机构：

[1] Texas A&M Univ, Dept Ind & Syst Engn, College Stn, TX 77843 USA

[2] Rice Univ, Houston, TX 77005 USA

[3] Univ Michigan Hlth Syst, Ann Arbor, MI 48109 USA

来源：

ANNALS OF OPERATIONS RESEARCH | 2012年 / 196卷 / 01期

关键词：

Breast cancer; Adjuvant endocrine therapy; Scheduling; Mathematical programming; QUALITY-OF-LIFE; POSTMENOPAUSAL WOMEN; RANDOMIZED-TRIAL; OPTIMIZATION APPROACH; TAMOXIFEN THERAPY; CHEMOTHERAPY; LETROZOLE; EXEMESTANE; ARIMIDEX; MODEL;

D O I：

10.1007/s10479-010-0741-y

中图分类号：

C93 [管理学]; O22 [运筹学];

学科分类号：

070105 ; 12 ; 1201 ; 1202 ; 120202 ;

摘要：

Based on the data available through published trial results, we build a mixed integer nonlinear programming (MINLP) model in order to find an optimal treatment plan for a given HR+ early stage breast cancer patient who is postmenopausal. The objective is to maximize the disease-free survival percentage at the end of the treatment period subject to the constraints on the risk of contralateral breast cancer and the risks of several side effects, including endometrial cancer, thromboembolic events, cardiovascular diseases, bone fractures, hot flushes, and vaginal bleeding. The results of numerical experiments suggest the effectiveness of some of the schedules currently used in practice, as well as suggest some attractive alternative treatment plans.

引用

页码：683 / 705

页数：23

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