Scheduling the adjuvant endocrine therapy for early stage breast cancer

被引：2
|
作者：
Kahruman, Sera [1 ]
Ulusal, Elif [1 ]
Butenko, Sergiy [1 ]
Hicks, Illya V. [2 ]
Diehl, Kathleen M. [3 ]
机构：
[1] Texas A&M Univ, Dept Ind & Syst Engn, College Stn, TX 77843 USA
[2] Rice Univ, Houston, TX 77005 USA
[3] Univ Michigan Hlth Syst, Ann Arbor, MI 48109 USA
来源：
ANNALS OF OPERATIONS RESEARCH | 2012年 / 196卷 / 01期
关键词：
Breast cancer; Adjuvant endocrine therapy; Scheduling; Mathematical programming; QUALITY-OF-LIFE; POSTMENOPAUSAL WOMEN; RANDOMIZED-TRIAL; OPTIMIZATION APPROACH; TAMOXIFEN THERAPY; CHEMOTHERAPY; LETROZOLE; EXEMESTANE; ARIMIDEX; MODEL;
D O I：
10.1007/s10479-010-0741-y
中图分类号：
C93 [管理学]; O22 [运筹学];
学科分类号：
070105 ; 12 ; 1201 ; 1202 ; 120202 ;
摘要：
Based on the data available through published trial results, we build a mixed integer nonlinear programming (MINLP) model in order to find an optimal treatment plan for a given HR+ early stage breast cancer patient who is postmenopausal. The objective is to maximize the disease-free survival percentage at the end of the treatment period subject to the constraints on the risk of contralateral breast cancer and the risks of several side effects, including endometrial cancer, thromboembolic events, cardiovascular diseases, bone fractures, hot flushes, and vaginal bleeding. The results of numerical experiments suggest the effectiveness of some of the schedules currently used in practice, as well as suggest some attractive alternative treatment plans.
引用
收藏
页码：683 / 705
页数：23
相关论文
共 50 条
  • [31] The Optimal Duration of Adjuvant Endocrine Therapy for Early Stage Breast Cancer—With What Drugs and for How Long?
    Stephen R. D. Johnston
    Belinda Yeo
    Current Oncology Reports, 2014, 16
  • [32] Optimal sequence of adjuvant endocrine and radiation therapy in early-stage breast cancer - A systematic review
    McGee, S. F.
    Mazzarello, S.
    Caudrelier, J. M.
    Lima, M. A. G.
    Hutton, B.
    Sienkiewicz, M.
    Stober, C.
    Fernandes, R.
    Ibrahim, M. F. K.
    Vandermeer, L.
    Hilton, J.
    Shorr, R.
    Fergusson, D.
    Clemons, M.
    CANCER TREATMENT REVIEWS, 2018, 69 : 132 - 142
  • [33] Lifestyle and quality of life in patients with early-stage breast cancer receiving adjuvant endocrine therapy
    Di Meglio, Antonio
    Soldato, Davide
    Presti, Daniele
    Vaz-Luis, Ines
    CURRENT OPINION IN ONCOLOGY, 2021, 33 (06) : 553 - 573
  • [34] Physician Survey of Timing of Adjuvant Endocrine Therapy Relative to Radiotherapy in Early Stage Breast Cancer Patients
    McGee, Sharon F.
    Vandermeer, Lisa
    Mazzarello, Sasha
    Sienkiewicz, Marta
    Stober, Carol
    Hutton, Brian
    Fergusson, Dean
    Hilton, John
    Caudrelier, Ean-Michel
    Blanchette, Phillip
    Clemons, Mark
    CLINICAL BREAST CANCER, 2019, 19 (01) : E40 - E47
  • [35] Optimizing adjuvant endocrine therapy in postmenopausal women with early stage breast cancer: a decision analysis.
    Punglia, RS
    Kuntz, KM
    Winer, E
    Weeks, JC
    Burstein, HJ
    BREAST CANCER RESEARCH AND TREATMENT, 2004, 88 : S58 - S59
  • [36] Cognitive sequelae of adjuvant endocrine therapy in older women treated for early-stage breast cancer
    Underwood, Emily A.
    Pritchard, Kathleen I.
    Jerzak, Katarzyna
    Lebovic, Gerald
    Elser, Christine
    Rochon, Paula
    Tierney, Mary C.
    CANCER RESEARCH, 2018, 78 (13)
  • [37] THE RISK OF ISCHEMIC HEART DISEASE WITH ADJUVANT ENDOCRINE THERAPY IN POSTMENOPAUSAL WOMEN WITH EARLY STAGE BREAST CANCER
    Abdel-Qadir, H.
    Fischer, H.
    Fu, L.
    Amir, E.
    Harvey, P.
    Lee, D. S.
    Rochon, P.
    Anderson, G.
    CANADIAN JOURNAL OF CARDIOLOGY, 2013, 29 (10) : S348 - S348
  • [38] Current controversies in extended adjuvant endocrine therapy for early breast cancer
    Snoj, Natasa
    Paridaens, Robert
    Cufer, Tanja
    CURRENT OPINION IN ONCOLOGY, 2008, 20 (06) : 627 - 633
  • [39] Adherence to Adjuvant Endocrine Therapy in Christchurch Women with Early Breast Cancer
    Robinson, B.
    Dijkstra, B.
    Davey, V.
    Tomlinson, S.
    Frampton, C.
    CLINICAL ONCOLOGY, 2018, 30 (01) : E9 - E15
  • [40] Racial disparities in initiation of adjuvant endocrine therapy of early breast cancer
    Katherine E. Reeder-Hayes
    Anne Marie Meyer
    Stacie B. Dusetzina
    Huan Liu
    Stephanie B. Wheeler
    Breast Cancer Research and Treatment, 2014, 145 : 743 - 751
12345