Ceramide kinase and the ceramide-1-phosphate/cPLA2 interaction as a therapeutic target

被引：32

作者：

Lamour, Nadia F. ^{[1
]}

Chalfant, Charles E. ^{[1
,2
,3
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA

[2] Massey Canc Ctr, Richmond, VA 23298 USA

[3] Hunter Holmes McGuire Vet Adm Med Ctr, Res & Dev, Richmond, VA 23249 USA

来源：

CURRENT DRUG TARGETS | 2008年 / 9卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.2174/138945008785132349

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ceramide kinase (CERK) was discovered more than a decade ago. Since then, numerous reports have been published demonstrating a role for CERK in various signal transduction pathways involved in inflammation, immunity or cancer. In this review, the biosynthesis of ceramide-1-phosphate (C1P) and the various roles of CERK and C1P in biological mechanisms will be overviewed. We will focus on the role of C1P in eicosanoid synthesis, more specifically, in the activation and translocation of cPLA2 alpha. Furthermore, the possible therapeutic relevance of inhibitors of these mechanisms is discussed.

引用

页码：674 / 682

页数：9

共 58 条

[1]

Bajjalieh S, 2000, METHOD ENZYMOL, V311, P207

[2]

BAJJALIEH SM, 1989, J BIOL CHEM, V264, P14354

[3] Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis [J].

Balestrieri, B ;

Hsu, VW ;

Gilbert, H ;

Leslie, CC ;

Han, WK ;

Bonventre, JV ;

Arm, JP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6691-6698

[4] Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice [J].

Blaine, SA ;

Meyer, AM ;

Hurteau, G ;

Wick, M ;

Hankin, JA ;

Murphy, RC ;

Dannenberg, AJ ;

Geraci, MW ;

Subbaramaiah, K ;

Nemenoff, RA .

CARCINOGENESIS, 2005, 26 (01) :209-217

[5] Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase - Comparative analysis to glucosylceramide and sphingomyelin [J].

Boath, Alistair ;

Graf, Christine ;

Lidome, Emilie ;

Ullrich, Thomas ;

Nussbaumer, Peter ;

Bornancin, Frederic .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (13) :8517-8526

[6] Characterization of a ceramide kinase-like protein [J].

Bornancin, FR ;

Mechtcheriakova, D ;

Stora, S ;

Graf, C ;

Wlachos, A ;

Dévay, P ;

Urtz, N ;

Baumruker, T ;

Billich, A .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2005, 1687 (1-3) :31-43

[7] Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain [J].

Carré, A ;

Graf, C ;

Stora, S ;

Mechtcheriakova, D ;

Csonga, R ;

Urtz, N ;

Billich, A ;

Baumruker, T ;

Bornancin, F .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 324 (04) :1215-1219

[8] TNF-α induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A2 activation [J].

Choi, IW ;

Sun-Kim ;

Kim, YS ;

Ko, HM ;

Im, SY ;

Kim, JH ;

You, HJ ;

Lee, YC ;

Lee, JH ;

Park, YM ;

Lee, HK .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (03) :537-543

[9] CYTOSOLIC PHOSPHOLIPASE A(2) [J].

CLARK, JD ;

SCHIEVELLA, AR ;

NALEFSKI, EA ;

LIN, LL .

JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING, 1995, 12 (2-3) :83-117

[10] Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel [J].

Colina, C ;

Flores, A ;

Rojas, H ;

Acosta, A ;

Castillo, C ;

Garrido, MD ;

Israel, A ;

DiPolo, R ;

Benaim, G .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2005, 436 (02) :333-345

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