Eukaryotic circadian systems: cycles in common

被引：69

作者：

Dunlap, JC ^{[1
]}

Loros, JJ ^{[1
]}

Liu, Y ^{[1
]}

Crosthwaite, SK ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA

来源：

GENES TO CELLS | 1999年 / 4卷 / 01期

关键词：

D O I：

10.1046/j.1365-2443.1999.00239.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Common regulatory patterns can now be discerned among eukaryotic circadian systems, extending from fungi through to mammals. Complexes of two distinct PAS domain-containing transcription factors play positive roles in clock-associated feedback loops by turning on classic clock proteins such as FRQ, PER and TIM. These in turn appear to act as negative elements, interfering with their own activation and thus giving rise to an oscillatory negative feedback loop. Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature.

引用

页码：1 / 10

页数：10

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