Circulating osteogenic precursor cells: Building bone from blood

被引:34
作者
Feehan, Jack [1 ,2 ,3 ]
Nurgali, Kulmira [1 ,2 ,4 ]
Apostolopoulos, Vasso [4 ]
Al Saedi, Ahmed [1 ,2 ,3 ]
Duque, Gustavo [1 ,2 ,3 ]
机构
[1] Univ Melbourne, Australian Inst Musculoskeletal Sci AIMSS, St Albans, Vic, Australia
[2] Western Hlth, St Albans, Vic, Australia
[3] Univ Melbourne, Melbourne Med Sch, Dept Med Western Hlth, Melbourne, Vic, Australia
[4] Victoria Univ, Inst Hlth & Sport, Footscray, Vic, Australia
来源
EBIOMEDICINE | 2019年 / 39卷
关键词
COP cells; Circulating osteogenic precursor cells; Circulating mesenchymal stem cells; Circulating osteoprogenitors; Stem cells; MESENCHYMAL STEM-CELLS; OSTEOBLAST PROGENITOR CELLS; MARROW STROMAL CELLS; OSTEOPROGENITOR CELLS; PERIPHERAL-BLOOD; DIFFERENTIATION; EXPRESSION; MONOCYTES; ORIGIN; INJURY;
D O I
10.1016/j.ebiom.2018.11.051
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Circulating osteogenic precursor (COP) cells constitute a recently discovered population of circulating progenitor cells with the capacity to form not only bone but other mesenchymal tissues. There is a small, but growing body of literature exploring these cells, but with a great deal of disagreement and contradiction within it. This review explores the origins and biological characterization of these cells, including the identification strategies used to isolate these cells from the peripheral blood. It also examines the available knowledge on the in vitro and in vivo behaviour of these cells, in the areas of plastic adherence, differentiation capacity, proliferation, and cellular homing. We also review the implications for future use of COP cells in clinical practice, particularly in the area of regenerative medicine and the treatment and assessment of musculoskeletal disease. (c) 2018 The Authors. Published by Elsevier B.V.
引用
收藏
页码:603 / 611
页数:9
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