Kif2a and HER2 expression in breast cancer tissue chip and their prognostic significance

被引：0

作者：

Zhu, Yan ^{[1
]}

Liu, Hong-Bin ^{[1
]}

Yang, Qi-Chang ^{[1
]}

Zhang, Xiao-Juan ^{[1
]}

Shen, Yi ^{[1
]}

Sun, Yong-Qiang ^{[2
]}

机构：

[1] First Peoples Hosp Nantong, Dept Pathol, Nantong, Jiangsu, Peoples R China

[2] First Peoples Hosp Nantong, Dept Surg, Nantong, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 08期

关键词：

Kif2a; HER2; tissue chip; breast cancer; immunohistochemistry; prognosis; CENTROMERE-ASSOCIATED KINESIN; OVEREXPRESSION; PROTEIN; CELLS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To investigate and evaluate the expression of Kif2a and HER2 in breast cancer tissue chip and their prognostic significance. Methods: The Kif2a and HER2 expression were detected in the cancer and adjacent tissues of 102 patients with breast cancer by tissue chip and immunohistochemistry. The 62 patients were recieved follow-up, and results were analyzed by single factor analysis or Cox regression analysis. Results: There was positive correlation between the expression of Kif2a and HER 2 in breast cancer with different TNM grade and lymph node metastasis (P < 0.05). Kif2a was positively correlated to HER2 (P < 0.01). In the following up of the 62 patients, the results of single factor analysis showed that the survival rate was correlated to the expression of Kif2a and HER2, TNM grade and lymph node metastasis, which was with independently prognostic significance by Cox regression analysis. Conclusion: Kif2a and HER2 expressions in breast cancer tissue were positively correlated to TNM grade and lymph node metastasis (P < 0.05). The expressions of Kif2a and HER2 were with important significance in the detection of potential metastasis of breast cancer and the evaluation of prognosis.

引用

页码：15394 / 15399

页数：6

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