The acute and sub-acute toxicity of C60/PVP complex in vivo

被引：2

作者：

Dumpis, Marina A. ^{[1
]}

Iljin, Viktor V. ^{[1
]}

Litasova, Elena V. ^{[1
]}

Nikolaev, Dmitry N. ^{[1
]}

Bulion, Valentina V. ^{[1
]}

Krylova, Irina B. ^{[1
]}

Okunevich, Irina V. ^{[1
]}

Rodionova, Olga M. ^{[1
]}

Safonova, Albina F. ^{[1
]}

Selina, Elena N. ^{[1
]}

Piotrovsky, Levon B. ^{[1
]}

机构：

[1] Inst Expt Med, Dept Neuropharmacol, Acad Pavlov Str 12, St Petersburg 197376, Russia

来源：

ADVANCES IN NANO RESEARCH | 2016年 / 4卷 / 03期

关键词：

fullerene C-60; polyvinylpyrrolidone; complex; toxicity; FULLERENE C-60; BIOLOGICAL SAFETY; CARBON NANOTUBES; WATER; ANTIOXIDANT; DERIVATIVES; SKIN; C60; IMPACT; VITRO;

D O I：

10.12989/anr.2016.4.3.167

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The detailed study of acute and sub-acute toxicity of the complex polyvinylpyrrolidon (PVP 20 kDa)-wrapped fullerene C-60 after intraperitoneal (ip) administration was carried out on adult male Wistar rats. The LD50 value of C-60/PVP complex was found to be 7, 8 g/kg. In sub-acute study which lasted for 30 days the rats were exposed to daily administration of the complex in the doses of 350 or 700 mg/kg. All animals survived during the study and had no significant changes in clinical signs, organ weight, hematological and biochemical parameters of blood. The electrophysiological properties of myocardium and the excretory function of kidneys remained normal. Histological analysis of liver, kidney and spleen at the end of the study also did not demonstrate toxic alterations. It was thus established that intraperitoneal administration of complex C-60/PVP has no toxic effect. These results suggest that C-60/PVP has no acute and sub-acute toxicity and is a perspective substance for potential application in biology and medicine.

引用

页码：167 / 179

页数：13

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