Slit is the midline repellent for the robe receptor in Drosophila

被引：779

作者：

Kidd, T ^{[1
]}

Bland, KS ^{[1
]}

Goodman, CS ^{[1
]}

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

CELL | 1999年 / 96卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(00)80589-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies suggested that Roundabout (Robo) is a repulsive guidance receptor on growth cones that binds to an unknown midline ligand. Here we present genetic evidence that Slit is the midline Robe ligand; a companion paper presents biochemical evidence that Slit binds Robe. Slit is a large extracellular matrix protein expressed by midline glia. In slit mutants, growth cones enter the midline but never leave it; they abnormally continue to express high levels of Robe while at the midline. slit and robe display dosage-sensitive genetic interactions, indicating that they function in the same pathway. slit is also required for migration of muscle precursors away from the midline. Slit appears to function as a short-range repellent controlling axon crossing of the midline and as a long-range chemorepellent controlling mesoderm migration away from the midline.

引用

页码：785 / 794

页数：10

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