Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model

被引：38

作者：

Mulero, Miquel ^{[2
]}

Rodriguez-Yanes, Esperanza ^{[2
]}

Nogues, Maria Rosa ^{[2
]}

Giralt, Montserrat ^{[2
]}

Romeu, Marta ^{[2
]}

Gonzalez, Salvador ^{[1
]}

Mallol, Jordi ^{[2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dermatol Serv, New York, NY 10022 USA

[2] Univ Rovira & Virgili, Sch Med & Hlth Sci, Dept Pharmacol, E-43201 Reus, Spain

来源：

EXPERIMENTAL DERMATOLOGY | 2008年 / 17卷 / 08期

关键词：

antioxidant; natural plant extract; photoprotection;

D O I：

10.1111/j.1600-0625.2007.00684.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In this report, we have addressed the effect of oral administration of a hydrophilic extract of the fern Polypodium leucotomos (PL) on the deleterious effects of ultraviolet radiation (UVR) on the levels of epidermal and plasmatic antioxidants in hairless rats. We have found that pretreatment with PL effectively reduced glutathione oxidation in both blood and epidermis, suggesting a potent systemic antioxidant effect. In addition, PL inhibited UVR-mediated Langerhans cell (LC) depletion. Our results demonstrate the efficacy of PL as an oral antioxidant and photoimmunoprotective agent and support its employment as a complement to topical sunscreens.

引用

页码：653 / 658

页数：6

共 28 条

[1] Botanical antioxidants in the prevention of photocarcinogenesis and photoaging [J].

Afaq, Farrukh ;

Mukhtar, Hasan .

EXPERIMENTAL DERMATOLOGY, 2006, 15 (09) :678-684

[2] An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model -: A pilot study [J].

Alcaraz, MV ;

Pathak, MA ;

Rius, F ;

Kollias, N ;

González, S .

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 1999, 15 (3-4) :120-126

[3] Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells [J].

Alonso-Lebrero, JL ;

Domínguez-Jiménez, C ;

Tejedor, R ;

Brieva, A ;

Pivel, JP .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2003, 70 (01) :31-37

[4]

Aubin F, 2003, EUR J DERMATOL, V13, P515

[5] ULTRAVIOLET-LIGHT AND FREE-RADICALS - AN IMMUNOLOGICAL THEORY OF EPIDERMAL CARCINOGENESIS [J].

AXELROD, M ;

SERAFIN, D ;

KLITZMAN, B .

PLASTIC AND RECONSTRUCTIVE SURGERY, 1990, 86 (03) :582-593

[6] UV-induced cutaneous photobiology [J].

Beissert, S ;

Granstein, RD .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1996, 31 (5-6) :381-404

[7] Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition [J].

Capote, R ;

Alonso-Lebrero, JL ;

García, F ;

Brieva, A ;

Pivel, JP ;

González, S .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2006, 82 (03) :173-179

[8] MODIFICATIONS OF GLUTATHIONE-S-TRANSFERASE (GST) ACTIVITY IN THE LAST PERIOD OF PREGNANCY IN RATS TREATED WITH BENZO(A)PYRENE (BP) [J].

CERVELLO, I ;

GIRALT, M ;

NOGUES, MR ;

ORTIN, F ;

PUERTO, AM ;

MALLOL, J .

PLACENTA, 1994, 15 (04) :431-440

[9] RODENT EPIDERMAL LANGERHANS CELLS DEMONSTRATE GREATER HISTOCHEMICAL SPECIFICITY FOR ADP THAN FOR ATP AND AMP [J].

CHAKER, MB ;

THARP, MD ;

BERGSTRESSER, PR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1984, 82 (05) :496-500

[10]

DELAFUENTE H, 2005, J INVEST DERMATOL 20, pA1

← 1 2 3 →