Phenylisotertronic acids from the TCM endophytic fungus Phyllosticta sp.

被引：6

作者：

Yang, Heng-Gang ^{[1
]}

Li, Jiao-Jiao ^{[1
]}

Chen, Shao-Meng ^{[1
]}

Mou, Lang-Ming ^{[1
]}

Zou, Jian ^{[1
]}

Wang, Chuan-Xi ^{[1
]}

Chen, Guo-Dong ^{[1
]}

Qin, Sheng-Ying ^{[3
]}

Yao, Xin-Sheng ^{[1
]}

Gao, Hao ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[2] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

[3] Jinan Univ, Affiliated Hosp 1, Clin Expt Ctr, Guangzhou 510632, Guangdong, Peoples R China

来源：

FITOTERAPIA | 2018年 / 124卷

基金：

中国国家自然科学基金;

关键词：

Phenylisotertronic acids; Isotertronic acids; Phyllosticta sp; Aeon's tatarinowii; TCM endophytic fungus; ALDOSE REDUCTASE INHIBITOR; ASPERGILLUS-TERREUS; BUTYROLACTONE DERIVATIVES; FERMENTATION PRODUCTS; TERMINAL ALKYNOATES; METABOLIC PRODUCTS; ISOTETRONIC ACIDS; BUTENOLIDE; WF-3681; STRAIN;

D O I：

10.1016/j.fitote.2017.10.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new phenylisotertronic acids (1a/1b, 2a, and 3a) were isolated from a TCM endophytic fungal strain Phyllosticta sp. J13-2-12Y obtained from the leaves of Acorus tatarinowii, along with two known ones (2b and 3b). Compounds 1 - 3 all existed as mixtures of enantiomers, and their corresponding optically pure enantiomers were successfully isolated by chiral HPLC. The structures of isolated compounds were determined by comprehensive spectroscopic analyses and X-ray diffraction. Their absolute configurations were determined by ECD experiments and quantum chemical calculations. In addition, the antimicrobial activities and the cytotoxicities of these three pairs of optically pure enantiomers (1a/1b, 2a/2b, and 3a/3b) had been evaluated.

引用

页码：86 / 91

页数：6

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