Corn oil enhancing hepatic lipid peroxidation induced by CCl4 does not aggravate liver fibrosis in rats

被引：20
作者：
Fang, Hsun-Lang [2 ]
Lin, Wen-Chuan [1 ]
机构：
[1] China Med Univ, Coll Med, Dept Pharmacol, Taichung 404, Taiwan
[2] China Med Univ, Coll Pharm, Grad Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2008年 / 46卷 / 06期
关键词：
carbon tetrachloride; 13,14-dihydro-15-keto-PGF(2 alpha); 8-iso-prostagiandin F-2 alpha; lipid peroxidation; liver fibrosis; malondialdehyde;
D O I：
10.1016/j.fct.2008.03.005
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Lipid peroxidation (LPO) is known to be associated with liver fibrosis in chronic liver injury. However, direct effects of the products of LPO on liver fibrogenesis have not been demonstrated. In this study, we examined the LPO products of carbon tetrachloride (CCl4) + corn oil to evaluate the effect of LPO products on liver fibrosis. CCl4 was given twice a week for 8 weeks. Corn oil was given daily to rats at a dose of 2 or 10 ml/kg via gastrogavage throughout the whole experiment period. CCl4 induced both cyclooxygenase (COX)-2 independent and COX-2 dependent LPO. COX-2 independent LPO was enhanced by corn oil treatment while no effect was reflected on COX-2 dependent LPO. CCl4-incluced liver fibrosis in rats was not aggravated by corn oil treatment. In addition, the amount of fatty liver induced by CCl4 was increased by corn oil treatment. Though the inflammation-related UCP-2 mRNA expression was induced by CCl4, it was not aggravated by the enhancement of corn oil. Conclusion: corn oil enriches polyunsaturated fatty acids through COX-2 independent pathways to increase LPO products that do not enhance liver fibrosis induced by CCl4. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2267 / 2273
页数：7
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