Genes Expression of Metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) Associated with Psoriasis

被引：28

作者：

Starodubtseva, N. L. ^{[1
]}

Sobolev, V. V. ^{[2
]}

Soboleva, A. G. ^{[2
]}

Nikolaev, A. A. ^{[2
]}

Bruskin, S. A. ^{[2
]}

机构：

[1] Moscow Inst Phys & Technol, Moscow 117303, Russia

[2] Russian Acad Sci, Vavilov Inst Gen Genet, Moscow 119991, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2011年 / 47卷 / 09期

关键词：

MATRIX METALLOPROTEINASES; METALLOELASTASE MMP-12; TUMOR INVASION; CELL DENSITY; GELATINASE-A; INFLAMMATION; MATRIX-METALLOPROTEINASE-2; PLASMA; AP-1; TRANSCRIPTION;

D O I：

10.1134/S102279541109016X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Using real-time polymerase chain reaction (RT-PCR), we measured mRNA amounts of matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-9, and MMP-12 genes in psoriatic lesions and unaffected skin of the same patients. We observed significant (about 15-fold) increase in the expression level of matrix metalloproteinase MMP-1 and MMP-12 genes associated with psoriasis. The results of our studies of MMP gene expression in cultured primary human keratinocytes treated with interleukin (IL)-17 have shown upregulation of MMP gene expression both in cultured keratinocytes and in psoriatic skin lesions. Therefore, upregulation of MMP genes in the skin affected by psoriasis could result from IL-17 effects on skin cells.

引用

页码：1117 / 1123

页数：7

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