The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure

被引：78

作者：

Tucker, Deirdre K. ^{[1
,2
]}

Macon, Madisa B. ^{[1
,2
]}

Strynar, Mark J. ^{[3
]}

Dagnino, Sonia ^{[4
]}

Andersen, Erik ^{[5
]}

Fenton, Suzanne E. ^{[2
]}

机构：

[1] Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC 27599 USA

[2] NIEHS, Natl Toxicol Program Lab, Div NTP, NIH, Res Triangle Pk, NC 27709 USA

[3] US EPA, Methods Dev & Applicat Branch, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA

[4] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA

[5] US EPA, Exposure Measurements & Anal Branch, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA

来源：

REPRODUCTIVE TOXICOLOGY | 2015年 / 54卷

关键词：

Perfluorooctanoic acid; Mammary gland; Puberty; CD-1; C57Bl/6; Vaginal opening; Estrous cycle; LACTATING MICE; BREAST-CANCER; MOUSE STRAINS; PREGNANCY; MEDIATE; TISSUES; BALB/C; FLUIDS; PUPS;

D O I：

10.1016/j.reprotox.2014.12.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Perfluorooctanoic acid (PFOA) is a developmental toxicant in mice, with varied strain outcomes depending on dose and period of exposure. The impact of PFOA on female mouse pubertal development at low doses (<= 1 mg/kg) has yet to be determined. Therefore, female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum concentrations similar to humans, were examined for pubertal onset, including mammary gland development. Pups demonstrated a shorter PFOA elimination half-life than that reported for adult mice. Prenatal exposure to PFOA caused significant mammary developmental delays in female offspring in both strains. Delays started during puberty and persisted into young adulthood; severity was dose-dependent. Also an evaluation of female serum hormone levels and pubertal timing onset revealed no effects of PFOA compared to controls in either strain. These data suggest that the mammary gland is more sensitive to early low level PFOA exposures compared to other pubertal endpoints, regardless of strain. Published by Elsevier Inc.

引用

页码：26 / 36

页数：11

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