共 53 条
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+-mediated apoptosis pathways in MCF-7/ADR and K562/ADR
被引:47
作者:

Sun, Yaoting
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Wang, Changyuan
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Meng, Qiang
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Liu, Zhihao
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Huo, Xiaokui
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Sun, Pengyuan
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Sun, Huijun
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Ma, Xiaodong
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Peng, Jinyong
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

Liu, Kexin
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
机构:
[1] Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, 9 West Sect,Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China
[2] Liaoning Dalian Med Univ, Prov Key Lab Pharmacokinet & Transport, Dalian, Liaoning, Peoples R China
基金:
中国国家自然科学基金;
关键词:
adriamycin;
dihydromyricetin;
multidrug resistance;
P-glycoprotein;
SORCIN;
CALCIUM-BINDING PROTEIN;
ENERGY-METABOLISM COMBINATION;
MULTIDRUG-RESISTANCE;
DRUG-RESISTANCE;
2-DEOXYGLUCOSE REVERSES;
CANCER;
CELLS;
EXPRESSION;
OVEREXPRESSION;
ACTIVATION;
D O I:
10.1002/jcp.26087
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Recently, a new target Ca2+-binding protein SORCIN was reported to participate in multidrug resistance (MDR) in cancer. Here we aim to investigate whether dihydromyricetin (DMY), a dihydroflavonol compound with anti-inflamatory, anti-oxidant, anti-bacterial and anti-tumor actions, reverses MDR in MCF-7/ADR and K562/ADR and to elucidate its potential molecular mechanism. DMY enhanced cytotoxicity of adriamycin (ADR) by downregulating MDR1 mRNA and P-gp expression through MAPK/ERK pathway and also inhibiting the function of P-gp significantly. Meanwhile, DMY decreased mRNA and protein expression of SORCIN, which resulted in elevating intracellular free Ca2+. Finally, we investigated co-administration ADR with DMY remarkably increased ADR-induced apoptosis. Further study showed DMY elevated ROS levels and caspase-12 protein expression, which signal apoptosis in endoplasmic reticulum. At the same time, proteins related to mitochondrial apoptosis were also changed such as Bcl-2, Bax, caspase-3, caspase-9, and PARP. Finally, nude mice model also demonstrated that DMY strengthened anti-tumor activity of ADR in vivo. In conclusion, DMY reverses MDR by downregulating P-gp, SORCIN expression and increasing free Ca2+, as well as, inducing apoptosis in MCF-7/ADR and K562/ADR. These fundamental findings provide evidence for further clinical research in application of DMY as an assistant agent in the treatment of cancer.
引用
收藏
页码:3066 / 3079
页数:14
相关论文
共 53 条
[1]
Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKCη with MDR1, MRP and LRP gene expression
[J].
Beck, J
;
Bohnet, B
;
Brügger, D
;
Bader, P
;
Dietl, J
;
Scheper, RJ
;
Kandolf, R
;
Liu, C
;
Niethammer, D
;
Gekeler, V
.
BRITISH JOURNAL OF CANCER,
1998, 77 (01)
:87-91

Beck, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Bohnet, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Brügger, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Bader, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Dietl, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Scheper, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Kandolf, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Liu, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Niethammer, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany

Gekeler, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Childrens Hosp, Dept Obstet & Gynecol, D-72070 Tubingen, Germany
[2]
Quercetin: A potential drug to reverse multidrug resistance
[J].
Chen, Chen
;
Zhou, Jane
;
Ji, Chunyan
.
LIFE SCIENCES,
2010, 87 (11-12)
:333-338

Chen, Chen
论文数: 0 引用数: 0
h-index: 0
机构:
Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

Zhou, Jane
论文数: 0 引用数: 0
h-index: 0
机构:
Zenith Diagnost Consultants, Redding, CA 96001 USA Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

Ji, Chunyan
论文数: 0 引用数: 0
h-index: 0
机构:
Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[3]
Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial
[J].
Chen, Shihui
;
Zhao, Xiaolan
;
Wan, Jing
;
Ran, Li
;
Qin, Yu
;
Wang, Xiaofang
;
Gao, Yanxiang
;
Shu, Furong
;
Zhang, Yong
;
Liu, Peng
;
Zhang, Qianyong
;
Zhu, Jundong
;
Mi, Mantian
.
PHARMACOLOGICAL RESEARCH,
2015, 99
:74-81

Chen, Shihui
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China
Foshan Hosp Tradit Chinese Med, Ctr Prevent Treatment Dis, Foshan 528000, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Zhao, Xiaolan
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Affiliated Hosp 1, Hlth Care Ctr Southwest Hosp, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Wan, Jing
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Ran, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Qin, Yu
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Wang, Xiaofang
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Affiliated Hosp 1, Hlth Care Ctr Southwest Hosp, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Gao, Yanxiang
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Shu, Furong
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Zhang, Yong
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Liu, Peng
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Zhang, Qianyong
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Zhu, Jundong
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China

Mi, Mantian
论文数: 0 引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China
[4]
Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway
[J].
Chen, Ting
;
Wang, Changyuan
;
Liu, Qi
;
Meng, Qiang
;
Sun, Huijun
;
Huo, Xiaokui
;
Sun, Pengyuan
;
Peng, Jinyong
;
Liu, Zhihao
;
Yang, Xiaobo
;
Liu, Kexin
.
CANCER BIOLOGY & THERAPY,
2015, 16 (01)
:106-114

Chen, Ting
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Wang, Changyuan
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Liu, Qi
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Meng, Qiang
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Sun, Huijun
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Huo, Xiaokui
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Sun, Pengyuan
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Peng, Jinyong
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Liu, Zhihao
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Yang, Xiaobo
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China

Liu, Kexin
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China Dalian Med Univ, Dept Clin Pharmacol, Coll Pharm, Dalian, Peoples R China
[5]
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
[J].
Chen, Zhaolin
;
Shi, Tianlu
;
Zhang, Lei
;
Zhu, Pengli
;
Deng, Mingying
;
Huang, Cheng
;
Hu, Tingting
;
Jiang, Ling
;
Li, Jun
.
CANCER LETTERS,
2016, 370 (01)
:153-164

Chen, Zhaolin
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China
Anhui Med Univ, Inst Liver Dis, Anhui Inst Innovat Drugs, Anhui Key Lab Bioact Nat Prod,Sch Pharm, Hefei 230032, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Shi, Tianlu
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China
Anhui Med Univ, Inst Liver Dis, Anhui Inst Innovat Drugs, Anhui Key Lab Bioact Nat Prod,Sch Pharm, Hefei 230032, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Zhang, Lei
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Zhu, Pengli
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Deng, Mingying
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Huang, Cheng
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Med Univ, Inst Liver Dis, Anhui Inst Innovat Drugs, Anhui Key Lab Bioact Nat Prod,Sch Pharm, Hefei 230032, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Hu, Tingting
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Med Univ, Inst Liver Dis, Anhui Inst Innovat Drugs, Anhui Key Lab Bioact Nat Prod,Sch Pharm, Hefei 230032, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Jiang, Ling
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China

Li, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Anhui Med Univ, Inst Liver Dis, Anhui Inst Innovat Drugs, Anhui Key Lab Bioact Nat Prod,Sch Pharm, Hefei 230032, Anhui, Peoples R China Anhui Prov Hosp, Dept Pharm, Hefei 230001, Anhui, Peoples R China
[6]
The BCL-2 Family Reunion
[J].
Chipuk, Jerry E.
;
Moldoveanu, Tudor
;
Llambi, Fabien
;
Parsons, Melissa J.
;
Green, Douglas R.
.
MOLECULAR CELL,
2010, 37 (03)
:299-310

Chipuk, Jerry E.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

Moldoveanu, Tudor
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

Llambi, Fabien
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

Parsons, Melissa J.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

Green, Douglas R.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA
[7]
ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
[J].
Choi, Young Hee
;
Yu, Ai-Ming
.
CURRENT PHARMACEUTICAL DESIGN,
2014, 20 (05)
:793-807

Choi, Young Hee
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14214 USA
Dongguk Univ, Coll Pharm, Seoul, South Korea SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14214 USA

Yu, Ai-Ming
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14214 USA
Univ Calif Davis, Med Ctr, Dept Biochem & Mol Med, Sacramento, CA 95817 USA SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14214 USA
[8]
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
[J].
Chou, Ting-Chao
.
PHARMACOLOGICAL REVIEWS,
2006, 58 (03)
:621-681

Chou, Ting-Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, Preclin Pharmacol Core Lab, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, Preclin Pharmacol Core Lab, New York, NY 10021 USA
[9]
Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer
[J].
Coley, Helen M.
.
CANCER TREATMENT REVIEWS,
2008, 34 (04)
:378-390

Coley, Helen M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Surrey, Postgrad Med Sch, Guildford GU2 7WG, Surrey, England Univ Surrey, Postgrad Med Sch, Guildford GU2 7WG, Surrey, England
[10]
Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells
[J].
Colotti, Gianni
;
Poser, Elena
;
Fiorillo, Annarita
;
Genovese, Ilaria
;
Chiarini, Valerio
;
Ilari, Andrea
.
MOLECULES,
2014, 19 (09)
:13976-13989

Colotti, Gianni
论文数: 0 引用数: 0
h-index: 0
机构:
CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy
CNR, Inst Mol Biol & Pathol, I-00185 Rome, Italy
Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy

Poser, Elena
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy

Fiorillo, Annarita
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy

Genovese, Ilaria
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy

Chiarini, Valerio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy

Ilari, Andrea
论文数: 0 引用数: 0
h-index: 0
机构:
CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy
CNR, Inst Mol Biol & Pathol, I-00185 Rome, Italy
Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy CNR, Inst Biol Mol Med & Nanobiotechnol, I-00185 Rome, Italy