Postsynaptic dopamine (D2)-mediated behavioural effects of high acute doses of artemisinin in rodents

被引：14

作者：

Amos, S ^{[1
]}

Chindo, BA ^{[1
]}

Abbah, J ^{[1
]}

Vongtau, HO ^{[1
]}

Edmond, I ^{[1
]}

Binda, L ^{[1
]}

Akah, PA ^{[1
]}

Wambebe, C ^{[1
]}

Gamaniel, KS ^{[1
]}

机构：

[1] NIPRD, Dept Pharmacol & Toxicol, Garki, Abuja, Nigeria

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 62卷 / 03期

关键词：

axtemisinin apomorphine; bromocriptine; behavior; dopamine (D-2) receptor; locomotor activity;

D O I：

10.1016/j.brainresbull.2003.09.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Artemisinin or qinghaosu is the active principle of quinghao (Artemisia annua L.) developed from Chinese traditional medicine, which is now widely used around the world against falciparum malaria. Behavioural effects of high acute doses of artemisinin were studied on spontaneous motor activity (SMA), exploratory behavior, apomorphine-induced stereotype behavior and pentobarbital sleeping time in mice and rats in order to provide additional evidence on its safety profile on the central nervous system (CN,S). Effects of the drug on bromocriptine-induced hyperactivity in short term reserpinised mice were also evaluated. Intraperitoneal (i.p.) injection of artemisinin at doses of 50 and 100 mg/kg, significantly (P < 0.05) reduced the SMA in mice, prolonged the pentobarbital sleeping time in rats, and attenuated the apomorphine-induced stereotypy in mice. Mice pretreated with reserpine, showed a significant decrease in locomotor activity compared to the saline-treated group. Bromocriptine, a D, receptor agonist, induced locomotor activity in mice pretreated with reserpine which was attenuated by artemisinin. The results suggest that artemisinin possesses sedative property, which may be mediated via postsynaptic dopamine (D-2) receptor in the CNS. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：255 / 260

页数：6

共 32 条

[1] Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats [J].