Synthesis and anticancer evaluation of certain α-methylene-γ-(4-substituted phenyl)-γ-butyrolactone bearing thymine, uracil, and 5-bromouracil

被引：18
|
作者：
Lee, KH
Huang, BR
Tzeng, CC [1 ]
机构：
[1] Kaohsiung Med Coll, Sch Chem, Kaohsiung 807, Taiwan
[2] Tajen Jr Coll Pharm, Dept Pharm, Pingtung, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期
关键词：
D O I：
10.1016/S0960-894X(98)00727-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Certain alpha-methylene-gamma-(4-substituted phenyl)-gamma-butyrolactone bearing thymine, uracil, and 5-bromouracil were synthesized and evaluated for their anticancer activity. These compounds demonstrated a strong growth inhibitory activity against leukemia cell lines. The anticancer potency for the substituents of the lactone C(gamma)-phenyl is in an order of 4-Ph > 4-Cl, 4-Br > 4-Me, 4-NO2 > 4-F. For the pyrimidine portion, 5-bromouracil is more potent than uracil and thymine. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：241 / 244
页数：4
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