Nickel-Catalyzed Cross-Coupling of Styrenyl Epoxides with Boronic Acids

被引：110
作者：
Nielsen, Daniel K. [1 ]
Doyle, Abigail G. [1 ]
机构：
[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 27期
关键词：
cross-coupling; epoxides; multicatalytic reactions; nickel; Suzuki-Miyaura reaction; HIGHLY FLUORINATED EPOXIDES; OXIDATIVE ADDITION; ALLYLIC ALCOHOLS; BOND FORMATION; PALLADIUM; ISOMERIZATION; ALKYLATION; ACTIVATION; ALDEHYDES; ETHERS;
D O I：
10.1002/anie.201101191
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Let's get multicatalytic! A Ni 0 catalyst complexed with a biaryldialkyl monophosphine ligand facilitates C-C bond formation between styrenyl epoxides and aryl boronic acids (see scheme). X-ray analysis of a catalytically active nickel/ligand complex supports a redox pathway involving C sp 3-O bond activation. A variety of α-substituted alcohols were generated with good reaction efficiency by a multicatalytic sequence. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：6056 / 6059
页数：4
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