[Ru(bpy)2(5-cyanouracil)2]2+ as a Potential Light-Activated Dual-Action Therapeutic Agent

被引：143

作者：

Garner, Robert N. ^{[2
]}

Gallucci, Judith C. ^{[2
]}

Dunbar, Kim R. ^{[1
]}

Turro, Claudia ^{[2
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

[2] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

INORGANIC CHEMISTRY | 2011年 / 50卷 / 19期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

PHOTOPHYSICAL PROPERTIES; RUTHENIUM(II) COMPLEXES; DNA PHOTOCLEAVAGE; LIGAND-EXCHANGE; CYTOTOXICITY; PHOTOCYTOTOXICITY; PHOTOSUBSTITUTION; PHOTOCHEMISTRY; BINDING; SERIES;

D O I：

10.1021/ic201615u

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The cation cis-[Ru(bpy)(2)(SCNU)(2)](2+) (bpy = 2,2'-bipyridine; SCNU = S-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced SCNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active SCNU and generating [Ru(bpy)(2)(H2O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.

引用

页码：9213 / 9215

页数：3

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