An outlook on microfluidics: the promise and the challenge

被引:225
作者
Battat, Sarah [1 ]
Weitz, David A. [1 ,2 ]
Whitesides, George M. [3 ]
机构
[1] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[2] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA
[3] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
关键词
HIGH-THROUGHPUT; DEVICES; FUTURE; GENERATION; PARTICLES; SYSTEMS; CELLS; CHIP;
D O I
10.1039/d1lc00731a
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This perspective considers ways in which the field of microfluidics can increase its impact by improving existing technologies and enabling new functionalities. We highlight applications where microfluidics has made or can make important contributions, including diagnostics, food safety, and the production of materials. The success of microfluidics assumes several forms, including fundamental innovations in fluid mechanics that enable the precise manipulation of fluids at small scales and the development of portable microfluidic chips for commercial purposes. We identify outstanding technical challenges whose resolution could increase the accessibility of microfluidics to users with both scientific and non-technical backgrounds. They include the simplification of procedures for sample preparation, the identification of materials for the production of microfluidic devices in both laboratory and commercial settings, and the replacement of auxiliary equipment with automated components for the operation of microfluidic devices.
引用
收藏
页码:530 / 536
页数:7
相关论文
共 91 条
[11]   Understanding Wax Printing: A Simple Micropatterning Process for Paper-Based Microfluidics [J].
Carrilho, Emanuel ;
Martinez, Andres W. ;
Whitesides, George M. .
ANALYTICAL CHEMISTRY, 2009, 81 (16) :7091-7095
[12]   Commercialization of microfluidic point-of-care diagnostic devices [J].
Chin, Curtis D. ;
Linder, Vincent ;
Sia, Samuel K. .
LAB ON A CHIP, 2012, 12 (12) :2118-2134
[13]   Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences [J].
Chiu, Daniel T. ;
deMello, Andrew J. ;
Di Carlo, Dino ;
Doyle, Patrick S. ;
Hansen, Carl ;
Maceiczyk, Richard M. ;
Wootton, Robert C. R. .
CHEM, 2017, 2 (02) :201-223
[14]   Emerging Point-of-care Technologies for Food Safety Analysis [J].
Choi, Jane Ru ;
Yong, Kar Wey ;
Choi, Jean Yu ;
Cowie, Alistair C. .
SENSORS, 2019, 19 (04)
[15]   Digital Microfluidics [J].
Choi, Kihwan ;
Ng, Alphonsus H. C. ;
Fobel, Ryan ;
Wheeler, Aaron R. .
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 5, 2012, 5 :413-440
[16]   Controllable monodisperse multiple emulsions [J].
Chu, Liang-Yin ;
Utada, Andrew S. ;
Shah, Rhutesh K. ;
Kim, Jin-Woong ;
Weitz, David A. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (47) :8970-8974
[17]   Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine [J].
Contreras-Naranjo, Jose C. ;
Wu, Hung-Jen ;
Ugaz, Victor M. .
LAB ON A CHIP, 2017, 17 (21) :3558-3577
[18]  
Cross R., 2021, Chem. Eng. News, V99, P16
[19]   Continuous-flow lithography for high-throughput microparticle synthesis [J].
Dendukuri, D ;
Pregibon, DC ;
Collins, J ;
Hatton, TA ;
Doyle, PS .
NATURE MATERIALS, 2006, 5 (05) :365-369
[20]   Lab-on-a-chip: microfluidics in drug discovery [J].
Dittrich, PS ;
Manz, A .
NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (03) :210-218