The role of anti-Mullerian hormone in gonadal development

被引：128
作者：
Josso, N [1 ]
Racine, C [1 ]
di Clemente, N [1 ]
Rey, R [1 ]
Xavier, F [1 ]
机构：
[1] Ecole Normale Super, INSERM, Unite Rech Endocrinol Dev, Dept Biol, F-92120 Montrouge, France
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1998年 / 145卷 / 1-2期
关键词：
Mullerian inhibiting factor (MIS); testis; ovary; meiosis; Leydig cell; steroidogenesis;
D O I：
10.1016/S0303-7207(98)00186-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Anti-Mullerian (AMH), a member of the transforming growth factor beta produced by immature Sertoli cells and, to a lesser degree, by granulosa cells from birth to the end of reproductive life, does not affect gonadal determination but has a negative effect upon gonadal development in both sexes. It blocks meiosis in fetal ovaries, leading to loss of germ cells and subsequent fibrous degeneration, and inhibits the transcription of aromatase and LH receptor. AMH also affects the development and function of the adult testis by blocking the differentiation of mesenchymal into Leydig cells and by independently decreasing the expression of steroidogenic enzymes. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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页码：3 / 7
页数：5
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