Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

被引：653
作者：
Brand, MD [1 ]
Esteves, TC [1 ]
机构：
[1] MRC, Dunn Human Nutr Unit, Cambridge, England
来源：
CELL METABOLISM | 2005年 / 2卷 / 02期
关键词：
D O I：
10.1016/j.cmet.2005.06.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.
引用
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页码：85 / 93
页数：9
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