Characterization and standardization of Sabin based inactivated polio vaccine: Proposal for a new antigen unit for inactivated polio vaccines

被引：37
|
作者：
Westdijk, Janny [1 ]
Brugmans, Debbie [1 ]
Martin, Javier [2 ]
van't Oever, Aart [1 ]
Bakker, Wilfried A. M. [1 ]
Levels, Lonneke [3 ]
Kersten, Gideon [1 ]
机构：
[1] Natl Inst Publ Hlth, Unit Vaccinol, NL-3720 AL Bilthoven, Netherlands
[2] Natl Inst Biol Stand & Controls, Potters Bar, Herts, England
[3] Netherlands Vaccine Inst, NL-3720 AL Bilthoven, Netherlands
来源：
VACCINE | 2011年 / 29卷 / 18期
关键词：
Inactivated polio vaccine; Sabin; Antigenicity; Immunogenicity; IMMUNOGENICITY; STRAINS; ASSAYS; IMMUNIZATION; BIRTH; RATS;
D O I：
10.1016/j.vaccine.2011.02.085
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
GMP-batches of Sabin-IPV were characterized for their antigenic and immunogenic properties. Antigenic fingerprints of Sabin-IPV reveal that the D-antigen unit is not a fixed amount of antigen but depends on antibody and assay type. Instead of the D-antigen unit we propose standardization of IPV based on a combination of protein amount for dose and D-antigenicity for quality of the vaccine. Although Sabin-IPV type 2 is less immunogenic than regular wild type IPV type 2, the immunogenicity (virus neutralizing titers) per microgram antigen for Sabin-IPV type 2 is in the same order as for wild type serotypes 1 and 3. The latter observations are in line with data from human trials. This suggests that a higher dose of Sabin-IPV type 2 to compensate for the lower rat immunogenicity may not be necessary. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3390 / 3397
页数：8
相关论文
共 50 条
  • [1] Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains
    Westdijk, Janny
    Koedam, Patrick
    Barro, Mario
    Steil, Benjamin P.
    Collin, Nicolas
    Vedvick, Thomas S.
    Bakker, Wilfried A. M.
    van der Ley, Peter
    Kersten, Gideon
    VACCINE, 2013, 31 (09) : 1298 - 1304
  • [2] A highly immunogenic UVC inactivated Sabin based polio vaccine
    Tobin, Gregory J.
    Tobin, John K.
    Wiggins, Taralyn J.
    Bushnell, Ruth V.
    Kozar, Arina V.
    Maale, Matthew F.
    MacLeod, David A.
    Meeks, Heather N.
    Daly, Michael J.
    Dollery, Stephen J.
    NPJ VACCINES, 2024, 9 (01)
  • [3] Polio endgame: the global introduction of inactivated polio vaccine
    Patel, Manish
    Zipursky, Simona
    Orenstein, Walt
    Garon, Julie
    Zaffran, Michel
    EXPERT REVIEW OF VACCINES, 2015, 14 (05) : 749 - 762
  • [4] A national reference for inactivated polio vaccine derived from Sabin strains in Japan
    Shirato, Haruko
    Someya, Yuichi
    Ochiai, Masaki
    Horiuchi, Yoshinobu
    Takahashi, Motohide
    Takeda, Naokazu
    Wakabayashi, Kengo
    Ouchi, Yasumitsu
    Ota, Yoshihiro
    Tano, Yoshio
    Abe, Shinobu
    Yamazaki, Shudo
    Wakita, Takaji
    VACCINE, 2014, 32 (40) : 5163 - 5169
  • [5] Development of an animal component free production process for Sabin inactivated polio vaccine
    Suarez-Zuluaga, Diego A.
    van der Pol, Leo A.
    van't Oever, Aart G.
    Bakker, Wilfried A. M.
    Thomassen, Yvonne E.
    VACCINE: X, 2022, 12
  • [6] The effect of formulation on spray dried Sabin inactivated polio vaccine
    Kanojia, Gaurav
    ten Have, Rimko
    Brugmans, Debbie
    Soema, Peter C.
    Frijlink, Henderik W.
    Amorij, Jean-Pierre
    Kersten, Gideon
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2018, 129 : 21 - 29
  • [7] Intranasal and sublingual delivery of inactivated polio vaccine
    Kraan, Heleen
    Soema, Peter
    Amorij, Jean-Pierre
    Kersten, Gideon
    VACCINE, 2017, 35 (20) : 2647 - 2653
  • [8] Poliovirus shedding after sequential immunization of Sabin-strain inactivated polio vaccines and oral attenuated polio vaccines
    Fu, Yuting
    Ma, Rufei
    Zhao, Zhimei
    Mo, Zhaojun
    Ying, Zhifang
    Li, Jing
    Ye, Hui
    Li, Guoliang
    Liu, Xiaochang
    Liang, Jiangli
    Ping, Ling
    Li, Jingyan
    Tao, Junhui
    Yang, Qinghai
    Wei, Dingkai
    Yi, Li
    Chen, Hongbo
    Wang, Jianfeng
    Jiang, Ruiju
    Yu, Lei
    Cai, Wei
    Yang, Wei
    Yue, Lei
    Xie, Mingxue
    Yin, Qiongzhou
    Pu, Jing
    Hong, Chao
    Cai, Lukui
    Deng, Yan
    Wen, Jiana
    Ma, Yan
    Gao, Na
    Wang, Xiaoyu
    Liao, Hongwei
    Ji, Qiuyan
    Ji, Guang
    Hu, Wenzhu
    Gu, Qin
    He, Xiaoyue
    Chu, Han
    Fu, Yixian
    Zhou, Jian
    Wen, Yu
    Yang, Xiaolei
    Li, Changgui
    Shi, Li
    Zhao, Ting
    Huang, Teng
    Yang, Jingsi
    NPJ VACCINES, 2025, 10 (01)
  • [9] Inactivated polio vaccine and global polio eradication
    Modlin, John F.
    LANCET INFECTIOUS DISEASES, 2012, 12 (02) : 93 - 94
  • [10] Antigenic and immunogenic properties of inactivated polio vaccine made from Sabin strains
    Kersten, G
    Hazendonk, T
    Beuvery, C
    VACCINE, 1999, 17 (15-16) : 2059 - 2066
12345