2-Aminoresorcinol is a potent α-glucosidase inhibitor

被引：22

作者：

Gao, Hong ^{[1
]}

Kawabata, Jun ^{[1
]}

机构：

[1] Hokkaido Univ, Lab Food Biochem, Grad Sch Agr, Div Appl Biosci,Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 02期

基金：

日本学术振兴会;

关键词：

alpha-glucosidase inhibitor; resorcinol; 6-aminoflavones; 2-aminoresorcinol;

D O I：

10.1016/j.bmcl.2007.11.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of aminoresorcinols and related compounds were tested for rat intestinal alpha-glucosidase inhibition and these results suggested that the 2-aminoresorcinol moiety of 6-amino-5,7-dihydroxyflavone (2) is important to exert the intestinal alpha-glucosidase inhibitory activity and 2-aminoresorcinol (4), itself, is a potent alpha-glucosidase inhibitor and inhibited sucrose-hydrolyzing activity of rat intestinal alpha-glucosidase uncompetitively. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：812 / 815

页数：4

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