A patient with two gliomas with independent oligodendroglioma and glioblastoma biology proved by DNA-methylation profiling: a case report and review of the literature

被引：5

作者：

Kraus, Theo F. J. ^{[1
]}

Schwartz, Christoph ^{[2
]}

Machegger, Lukas ^{[3
]}

Zellinger, Barbara ^{[1
]}

Hoelzl, Dorothee ^{[1
]}

Schlicker, Hans U. ^{[1
]}

Poeppe, Johannes ^{[2
]}

Ladisich, Barbara ^{[2
]}

Spendel, Mathias ^{[2
]}

Kral, Michael ^{[2
]}

Sotlar, Karl ^{[1
]}

机构：

[1] Paracelsus Med Univ, Univ Hosp Salzburg, Inst Pathol, Mullner Hauptstr 48, A-5020 Salzburg, Austria

[2] Paracelsus Med Univ, Univ Hosp Salzburg, Dept Neurosurg, Ignaz Harrer Str 79, A-5020 Salzburg, Austria

[3] Paracelsus Med Univ, Univ Hosp Salzburg, Inst Neuroradiol, Ignaz Harrer Str 79, A-5020 Salzburg, Austria

来源：

BRAIN TUMOR PATHOLOGY | 2022年 / 39卷 / 02期

关键词：

Biomarker; Glioma; Oligodendroglioma; Glioblastoma; DNA-methylation profiling; CENTRAL-NERVOUS-SYSTEM; CLASSIFICATION; TUMORS;

D O I：

10.1007/s10014-021-00423-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Here, we report on a patient presenting with two histopathologically distinct gliomas. At the age of 42, the patient underwent initial resection of a right temporal oligodendroglioma IDH mutated 1p/19q co-deleted WHO Grade II followed by adjuvant radiochemotherapy with temozolomide. 15 months after initial diagnosis, the patient showed right hemispheric tumor progression and an additional new left frontal contrast enhancement in the subsequent imaging. A re-resection of the right-sided tumor and resection of the left frontal tumor were conducted. Neuropathological work-up showed recurrence of the right-sided oligodendroglioma with features of an anaplastic oligodendroglioma WHO Grade III, but a glioblastoma WHO grade IV for the left frontal lesion. In depth molecular profiling revealed two independent brain tumors with distinct molecular profiles of anaplastic oligodendroglioma IDH mutated 1p/19q co-deleted WHO Grade III and glioblastoma IDH wildtype WHO grade IV. This unique and rare case of a patient with two independent brain tumors revealed by in-depth molecular work-up and epigenomic profiling emphasizes the importance of integrated work-up of brain tumors including methylome profiling for advanced patient care.

引用

页码：111 / 119

页数：9

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