Anticancer Mechanisms of Berberine: A Good Choice for Glioblastoma Multiforme Therapy

被引：12

作者：

Bibak, Bahram ^{[1
,2
]}

Shakeri, Farzaneh ^{[1
,2
]}

Keshavarzi, Zakieh ^{[1
,2
]}

Mollazadeh, Hamid ^{[1
,2
]}

Javid, Hossein ^{[3
]}

Jalili-Nik, Mohammad ^{[3
]}

Sathyapalan, Thozhukat ^{[4
]}

Afshari, Amir R. ^{[2
]}

Sahebkar, Amirhossein ^{[5
,6
,7
,8
,9
]}

机构：

[1] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Sch Med, Bojnurd, Iran

[2] North Khorasan Univ Med Sci, Fac Med, Dept Physiol & Pharmacol, Bojnurd, Iran

[3] Mashhad Univ Med Sci, Fac Med, Dept Med Biochem, Mashhad, Razavi Khorasan, Iran

[4] Univ Hull, Acad Diabet Endocrinol & Metab, Hull York Med Sch, Kingston Upon Hull, N Humberside, England

[5] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[7] Univ Western Australia, Sch Med, Perth, WA, Australia

[8] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol & Nanotechnol, Mashhad, Razavi Khorasan, Iran

[9] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Razavi Khorasan, Iran

来源：

CURRENT MEDICINAL CHEMISTRY | 2022年 / 29卷 / 26期

关键词：

Glioblastoma multiforme; phytomolecules; berberine; autophagy; apoptosis; malignant brain tumor; CELL-CYCLE ARREST; TO-MESENCHYMAL TRANSITION; PROSTATE-CANCER CELLS; NF-KAPPA-B; DOWN-REGULATION; INDUCED APOPTOSIS; MITOCHONDRIAL APOPTOSIS; INDUCED CYTOTOXICITY; INTRANASAL DELIVERY; SUPPRESSES GROWTH;

D O I：

10.2174/0929867329666220224112811

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by regulating several signaling pathways. Berberine, an isoquinoline alkaloid, has various pharmacological applications to combat severe diseases like cancer. Mechanistically, it inhibits cell proliferation and invasion, suppresses tumor angiogenesis, and induces cell apoptosis. The antitumoral effect of berberine in GBM is increasingly recognized. This review sheds new light on the regulatory signaling mechanisms of berberine in various cancers, proposing its potential role as a therapeutic agent for GBM. left-to-right mark

引用

页码：4507 / 4528

页数：22

共 192 条

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