Positional cloning of a novel gene influencing asthma from Chromosome 2q14

被引：239

作者：

Allen, M

Heinzmann, A

Noguchi, E

Abecasis, G

Broxholme, J

Ponting, CP

Bhattacharyya, S

Tinsley, J

Zhang, YM

Holt, R

Jones, EY

Lench, N

Carey, A

Jones, H

Dickens, NJ

Dimon, C

Nicholls, R

Baker, C

Xue, LZ

Townsend, E

Kabesch, M

Weiland, SK

Carr, D

von Mutius, E

Adcock, IM

Barnes, PJ

Lathrop, GM

Edwards, M

Moffatt, MF

Cookson, WOCM ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Oxagen, Milton Pk, Oxon, England

[3] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 2JD, England

[4] Univ Munich, Childrens Hosp, D-8000 Munich, Germany

[5] Univ Ulm, Dept Epidemiol, Ulm, Germany

[6] Natl Heart & Lung Inst, Dept Thorac Med, London, England

[7] Ctr Natl Genotypage, Evry, France

来源：

NATURE GENETICS | 2003年 / 35卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng1256

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Asthma is a common disease in children and young adults. Four separate reports have linked asthma and related phenotypes to an ill-defined interval between 2q14 and 2q32 (refs. 1 4), and two mouse genome screens have linked bronchial hyper-responsiveness to the region homologous to 2q14 ( refs. 5,6). We found and replicated association between asthma and the D2S308 microsatellite, 800 kb distal to the IL1 cluster on 2q14. We sequenced the surrounding region and constructed a comprehensive, high-density, single-nucleotide polymorphism (SNP) linkage disequilibrium (LD) map. SNP association was limited to the initial exons of a solitary gene of 3.6 kb (DPP10), which extends over 1 Mb of genomic DNA. DPP10 encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy.

引用

页码：258 / 263

页数：6

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