Positional cloning of a novel gene influencing asthma from Chromosome 2q14

被引：239
作者：
Allen, M
Heinzmann, A
Noguchi, E
Abecasis, G
Broxholme, J
Ponting, CP
Bhattacharyya, S
Tinsley, J
Zhang, YM
Holt, R
Jones, EY
Lench, N
Carey, A
Jones, H
Dickens, NJ
Dimon, C
Nicholls, R
Baker, C
Xue, LZ
Townsend, E
Kabesch, M
Weiland, SK
Carr, D
von Mutius, E
Adcock, IM
Barnes, PJ
Lathrop, GM
Edwards, M
Moffatt, MF
Cookson, WOCM [1 ]
机构：
[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
[2] Oxagen, Milton Pk, Oxon, England
[3] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 2JD, England
[4] Univ Munich, Childrens Hosp, D-8000 Munich, Germany
[5] Univ Ulm, Dept Epidemiol, Ulm, Germany
[6] Natl Heart & Lung Inst, Dept Thorac Med, London, England
[7] Ctr Natl Genotypage, Evry, France
来源：
NATURE GENETICS | 2003年 / 35卷 / 03期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/ng1256
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Asthma is a common disease in children and young adults. Four separate reports have linked asthma and related phenotypes to an ill-defined interval between 2q14 and 2q32 (refs. 1 4), and two mouse genome screens have linked bronchial hyper-responsiveness to the region homologous to 2q14 ( refs. 5,6). We found and replicated association between asthma and the D2S308 microsatellite, 800 kb distal to the IL1 cluster on 2q14. We sequenced the surrounding region and constructed a comprehensive, high-density, single-nucleotide polymorphism (SNP) linkage disequilibrium (LD) map. SNP association was limited to the initial exons of a solitary gene of 3.6 kb (DPP10), which extends over 1 Mb of genomic DNA. DPP10 encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy.
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收藏
页码：258 / 263
页数：6
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