Damage to hair follicles by normal-mode ruby laser pulses

被引:265
作者
Grossman, MC [1 ]
Dierickx, C [1 ]
Farinelli, W [1 ]
Flotte, T [1 ]
Anderson, RR [1 ]
机构
[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA
关键词
D O I
10.1016/S0190-9622(96)90111-5
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Although many temporary treatments exist for hirsutism and hypertrichosis, a practical and permanent hair removal treatment is needed. Objective: Our purpose was to study the use of normal-mode ruby laser pulses (694 nm, 270 mu sec, 6 mm beam diameter) for hair follicle destruction by selective photothermolysis. Methods: Histologically assessed damage in ex vivo black-haired dog skin after the use of different laser fluences was used to design a human study; 13 volunteers with brown or black hair were exposed to normal-mode ruby laser pulses at fluences of 30 to 60 J/cm(2), delivered to both shaved and wax-epilated skin sites. An optical delivery device designed to maximize light delivery to the reticular dermis was used. Hair regrowth was assessed at 1, 3, and 6 months after exposure by counting terminal hairs. Results: Fluence-dependent selective thermal injury to follicles was observed histologically. There was a significant delay in hair growth in all subjects at all laser-treated sites compared with the unexposed shaven and epilated control sites. At 6 months, there was significant hair loss only in the areas shaved before treatment at the highest fluence. At 6 months, four subjects had less than 50%, regrowth, two of whom showed no change between 3 and 6 months. Transient pigmentary changes were observed; there was no securing. Conclusion: Selective photothermolysis of hair follicles with the normal-mode ruby laser produces a growth delay consistent with induction of prolonged telogen with apparently permanent hair removal in some cases.
引用
收藏
页码:889 / 894
页数:6
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