An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease

被引：172

作者：

Celli, Bartolome R. ^{[1
]}

Decramer, Marc ^{[1
]}

Wedzicha, Jadwiga A. ^{[1
]}

Wilson, Kevin C. ^{[1
]}

Agusti, Alvar ^{[1
]}

Griner, Gerard J. ^{[1
]}

MacNee, William ^{[1
]}

Make, Barry J. ^{[1
]}

Rennard, Stephen I. ^{[1
]}

Stockley, Robert A. ^{[1
]}

Vogelmeier, Claus ^{[1
]}

Anzueto, Antonio ^{[1
]}

Au, David H. ^{[1
]}

Barnes, Peter J. ^{[1
]}

Burgel, Pierre-Regis ^{[1
]}

Calverley, Peter M. ^{[1
]}

Casanova, Ciro ^{[1
]}

Clini, Enrico M. ^{[1
]}

Cooper, Christopher B. ^{[1
]}

Coxson, Harvey O. ^{[1
]}

Dusser, Daniel J. ^{[1
]}

Fabbri, Leonardo M. ^{[1
]}

Fahy, Bonnie ^{[1
]}

Ferguson, Gary T. ^{[1
]}

Fisher, Andrew ^{[1
]}

Fletcher, Monica J. ^{[1
]}

Hayot, Maurice ^{[1
]}

Hurst, John R. ^{[1
]}

Jones, Paul W. ^{[1
]}

Mahler, Donald A. ^{[1
]}

Maltais, Francois ^{[1
]}

Mannino, David M. ^{[1
]}

Martinez, Fernando J. ^{[1
]}

Miravitlles, Marc ^{[1
]}

Meek, Paula M. ^{[1
]}

Papi, Alberto ^{[1
]}

Rabe, Klaus F. ^{[1
]}

Roche, Nicolas ^{[1
]}

Sciurba, Frank C. ^{[1
]}

Sethi, Sanjay ^{[1
]}

Siafakas, Nikos ^{[1
]}

Sin, Don D. ^{[1
]}

Soriano, Joan B. ^{[1
]}

Stoller, James K. ^{[1
]}

Tashkin, Donald P. ^{[1
]}

Troosters, Thierry ^{[1
]}

Verleden, Geert M. ^{[1
]}

Verschakelen, Johny ^{[1
]}

Vestbo, Jorgen ^{[1
]}

Walsh, John W. ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Ctr Pulm, Amer Thorac Soc,Documents & Med Affairs, R-304,72 E Concord St, Boston, MA 02118 USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2015年 / 191卷 / 07期

关键词：

POSITIVE-PRESSURE VENTILATION; AIR-FLOW OBSTRUCTION; RANDOMIZED CONTROLLED-TRIAL; TERM OXYGEN-THERAPY; SMOKING-CESSATION; NONINVASIVE VENTILATION; COMPUTED-TOMOGRAPHY; LUNG-FUNCTION; DOUBLE-BLIND; BODE INDEX;

D O I：

10.1164/rccm.201501-0044ST

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Methods: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. Results: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Conclusions: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered Outcomes.

引用

页码：831 / 844

页数：14

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