Chimeric hepatitis B virus (HBV)/hepatitis C virus (HCV) subviral envelope particles induce efficient anti-HCV antibody production in animals pre-immunized with HBV vaccine

被引：21
作者：
Beaumont, Elodie
Roingeard, Philippe [1 ]
机构：
[1] Univ Tours, INSERM, U966, Tours, France
来源：
VACCINE | 2015年 / 33卷 / 08期
关键词：
Viral hepatitis; Preventive vaccination; Subviral envelope particles; Immune response; Liver diseases; IMMUNOGENICITY;
D O I：
10.1016/j.vaccine.2015.01.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of an effective, affordable prophylactic vaccine against hepatitis C virus (HCV) remains a medical priority. The recently described chimeric HBV-HCV subviral envelope particles could potentially be used for this purpose, as they could be produced by industrial procedures adapted from those established for the hepatitis B virus (HBV) vaccine. We show here, in an animal model, that pre-existing immunity acquired through HBV vaccination does not influence the immunogenicity of the HCV E2 protein presented by these chimeric particles. Thus, these chimeric HBV HCV subviral envelope particles could potentially be used as a booster in individuals previously vaccinated against HBV, to induce protective immunity to HCV. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：973 / 976
页数：4
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