Revealing the crosstalk between nasopharyngeal carcinoma and immune cells in the tumor microenvironment

被引：27

作者：

Jiang, Jianyun ^{[1
,2
,3
]}

Ying, Hongmei ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

[3] Shanghai Key Lab Radiat Oncol, Shanghai 200032, Peoples R China

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2022年 / 41卷 / 01期

关键词：

Nasopharyngeal carcinoma; Tumor microenvironment; Immune cell; Immunotherapy; EPSTEIN-BARR-VIRUS; INDOLEAMINE 2,3-DIOXYGENASE; LYMPHOID STRUCTURES; GLUCOSE-METABOLISM; ANTITUMOR-ACTIVITY; SUPPRESSOR-CELLS; B-CELLS; EXPRESSION; RECURRENT; CETUXIMAB;

D O I：

10.1186/s13046-022-02457-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nasopharyngeal carcinoma (NPC) arises from the epithelial cells located in the nasopharynx and has a distinct geographic distribution. Chronic Epstein-Barr virus (EBV) infection, as its most common causative agents, can be detected in 100% of NPC types. In-depth studies of the cellular and molecular events leading to immunosuppression in NPC have revealed new therapeutic targets and diverse combinations that promise to benefit patients with highly refractory, advanced and metastatic NPC. This paper reviews the mechanisms by which NPC cells to circumvent immune surveillance and approaches being attempted to restore immunity. We integrate existing insights into anti-NPC immunity and molecular signaling pathways as well as targeting therapies in anticipation of broader applicability and effectiveness in advanced metastatic NPC.

引用

页数：12

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