Regulation of hepatocyte behaviors by galactose-carrying polymers through receptor-mediated mechanism

被引：15

作者：

Cho, C. S.

Hoshiba, T.

Harada, I.

Akaike, T. ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151921, South Korea

[2] Tokyo Inst Technol, Dept Biomol Engn, Yokohama, Kanagawa 2268501, Japan

[3] Natl Inst Math Sci, Ctr Biomat, Tsukuba, Ibaraki 3050044, Japan

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2007年 / 67卷 / 11期

关键词：

hepatocyte; galactose-carrying polymers; receptor-mediated mechanism; PVLA; extracellular matrix;

D O I：

10.1016/j.reactfunctpolym.2007.07.044

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In liver tissue engineering, the development of appropriate extracellular matrix (ECM) is important because hepatocytes are anchorage-dependent cells and they rapidly lose liver-specific functions and viability in vitro. Therefore, it is very important to regulate galactose-mediated hepatocyte recognition to enhance selective interactions between galactose-carrying polymers and hepatocytes and liver-specific functions. In this review, to regulate hepatocyte behaviors by galactose-carrying polymers, the effect of physico-chemical properties of galactose-carrying polymers, cellular environment, medium composition and dynamic culture system were explained. Moreover, to understand the regulation mechanism of hepatocyte behaviors by galactose-carrying polymers, intracellular signal transduction in the hepatocytes by galactose-carrying polymers was also discussed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1301 / 1310

页数：10

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