Ru@CeO2 yolk shell nanozymes: Oxygen supply in situ enhanced dual chemotherapy combined with photothermal therapy for orthotopic/subcutaneous colorectal cancer

被引：107

作者：

Zhu, Xufeng ^{[1
]}

Gong, Youcong ^{[1
]}

Liu, Yanan ^{[1
]}

Yang, Chunhua ^{[1
]}

Wu, Sijie ^{[1
]}

Yuan, Guanglong ^{[1
]}

Guo, Xian ^{[1
]}

Liu, Jie ^{[1
]}

Qin, Xiuying ^{[1
]}

机构：

[1] Jinan Univ, Coll Chem & Mat Sci, Dept Chem, Guangzhou 510632, Peoples R China

来源：

BIOMATERIALS | 2020年 / 242卷

基金：

中国国家自然科学基金;

关键词：

Tumor hypoxia; Dual-chemotherapy; Photothermal therapy; Metastasis; Colorectal cancer; POLY(ETHYLENE GLYCOL); PROTEIN RESISTANCE; DRUG-DELIVERY; GOLD; NANOPARTICLES; NANOSPHERES; COMBINATION; NANOSHELLS; INTERFACE; MICELLES;

D O I：

10.1016/j.biomaterials.2020.119923

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hypoxia is an important factor in forming multidrug resistance, recurrence and metastasis in solid tumors. Nanozymes respond to tumor microenvironment for tumor-specific treatment is a new and effective strategy. In this study, one-pot method was used to synthesize hollow Ru@CeO2 yolk shell nanozymes (Ru@CeO2 YSNs), which possess excellent light-to-heat conversion efficiency and catalytic performance. Antitumor drug ruthenium complex (RBT) and resveratrol (Res) were dual-loaded in Ru@CeO2 YSNs, and a double outer layer structure using polyethylene glycol was constructed to form dual-drug delivery system (Ru@CeO2-RBT/ResDPEG) that was released on demand. The double outer layer structure increased the biocompatibility of Ru@CeO2 YSNs and effectively prolong the circulation time in blood. Ru@CeO2-RBT/Res-DPEG catalyzes endogenous H2O2 to produce oxygen, which achieve in situ oxygen supply and enhanced dual-chemotherapy and photothermal therapy (PTT) for colorectal cancer. In vitro studies found that Ru@CeO2-RBT/Res-DPEG has good tumor penetration depth and antitumor effect. In addition, Ru@CeO2-RBT/Res-DPEG can alleviate tumor hypoxia, and inhibit metastasis and recurrence of orthotopic and subcutaneous colorectal cancer. Accordingly, the study shows that yolk shell nanozymes can be used as an efficient synergistic system for dual-chemotherapy and PTT to kill tumor and inhibit orthotopic colorectal cancer metastasis and recurrence.

引用

页数：13

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