Targeting ALT: The role of alternative lengthening of telomeres in pathogenesis and prevention of cancer

被引：15

作者：

Bollmann, F. Mathias ^{[1
]}

机构：

[1] Dept Hematol & Internal Oncol, Asklepios Klin Altona, D-22763 Hamburg, Germany

来源：

CANCER TREATMENT REVIEWS | 2007年 / 33卷 / 08期

关键词：

ALT; telomere; cancer; senescence; crisis; recombination; tumor;

D O I：

10.1016/j.ctrv.2007.08.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomere shortening in the course of cell divisions plays an important rote in both suppression and pathogenesis of cancer. Telomere maintenance mechanisms such as telomerase and alternative lengthening of telomeres (ALT) are essential for long-term tumor growth. Consequently, interdiction of telomere lengthening has been proposed as an anti-cancer treatment but requires insight in the genes and pathways involved. In this article, the molecular and functional details of ALT are reviewed, and proposed next steps towards a therapy aimed at preventing ALT in human cancers are described. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：704 / 709

页数：6

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