Effects of preparation conditions on the monodispersity of albumin microspheres

被引：29

作者：

El-Mahdy, M

Ibrahim, ES

Safwat, S

El-Sayed, A

Ohshima, H

Makino, K

Muramatsu, N

Kondo, T

机构：

[1] Sci Univ Tokyo, Fac Pharmaceut Sci, Shinjuku Ku, Tokyo 162, Japan

[2] Assiut Univ, Fac Pharm, Assiut, Egypt

来源：

JOURNAL OF MICROENCAPSULATION | 1998年 / 15卷 / 05期

关键词：

microsphere; albumin; monodisperse; emulsification; membrane;

D O I：

10.3109/02652049809008248

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Monodisperse albumin microspheres were successfully prepared by both chemical or thermal hardening methods via membrane emulsification using microporous glass membranes with uniform pore sizes. The monodispersity of the microspheres was found to depend strongly on parameters such as albumin concentration, emulsifier concentration, and volume ratio of the internal aqueous phase (albumin solution) to the dispersion medium (organic solvent). The optimum conditions for obtaining monodisperse albumin microspheres are described.

引用

页码：661 / 673

页数：13

共 30 条

[21] MATHEMATICAL-MODEL FOR THE SELECTIVE DEPOSITION OF INHALED PHARMACEUTICALS [J].