Enantioconservative synthesis and ring closing metathesis of disubstituted dialkenic amides

被引：26

作者：

Sauriat-Dorizon, H ^{[1
]}

Guibé, F ^{[1
]}

机构：

[1] Univ Paris Sud, Inst Chim Mol Orsay, CNRS, Lab React Organ Select, F-91405 Orsay, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 37期

关键词：

lactam; metathesis; peptide analogues;

D O I：

10.1016/S0040-4039(98)01432-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically pure disubstituted dialkenic amides 2, which are direct precursors of Z-ethylenic pseudopeptides 1, are readily synthesized and then cyclized to lactams 3 in the presence of Grubbs' ruthenium-based metathesis catalysts with total conservation of enantiomeric purity. (C) 1998 Elsevier Science Lid. All rights reserved.

引用

页码：6711 / 6714

页数：4

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