Multiplexed NIR-II Probes for Lymph Node-Invaded Cancer Detection and Imaging-Guided Surgery

被引：233

作者：

Tian, Rui ^{[1
,2
]}

Ma, Huilong ^{[3
]}

Zhu, Shoujun ^{[1
,4
]}

Lau, Joseph ^{[2
]}

Ma, Rui ^{[3
]}

Liu, Yijing ^{[2
]}

Lin, Lisen ^{[2
]}

Chandra, Swati ^{[2
]}

Wang, Sheng ^{[2
]}

Zhu, Xingfu ^{[3
]}

Deng, Hongzhang ^{[2
]}

Niu, Gang ^{[2
]}

Zhang, Mingxi ^{[5
]}

Antaris, Alexander L. ^{[6
]}

Hettie, Kenneth S. ^{[7
]}

Yang, Bai ^{[4
]}

Liang, Yongye ^{[3
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] First Hosp Jilin Univ, Minist Educ, Key Lab Organ Regenerat & Transplantat, Changchun 130061, Peoples R China

[2] NIBIB, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA

[3] Southern Univ Sci & Technol, Shenzhen Key Lab Printed Organ Elect, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China

[4] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

[5] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China

[6] Intuit Surg, Kifer Rd, Sunnyvale, CA 94086 USA

[7] Stanford Univ, Sch Med, Dept Radiol, MIPS, Stanford, CA 94305 USA

来源：

ADVANCED MATERIALS | 2020年 / 32卷 / 11期

基金：

美国国家科学基金会;

关键词：

multiplexed NIR-II imaging; NIR-II fluorophores; NIR-II image-guided surgery; NIR-II imaging; tumor metastasis detection; INDOCYANINE GREEN; PHOTOTHERMAL THERAPY; FLUOROPHORES; NANOPARTICLES; METASTASES; AGENT; TUMOR;

D O I：

10.1002/adma.201907365

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tumor-lymph node (LN) metastasis is the dominant prognostic factor for tumor staging and therapeutic decision-making. However, concurrently visualizing metastasis and performing imaging-guided lymph node surgery is challenging. Here, a multiplexed-near-infrared-II (NIR-II) is reported in vivo imaging system using nonoverlapping NIR-II probes with markedly suppressed photon scattering and zero-autofluorescence, enabling visualization of the metastatic tumor and the tumor metastatic proximal LNs resection. A bright and tumor-seeking donor-acceptor-donor (D-A-D) dye, IR-FD, is screened for primary/metastatic tumor imaging in the NIR-IIa (1100-1300 nm) window. This optimized D-A-D dye exhibits greatly improved quantum yield of organic D-A-D fluorophores in aqueous solutions (approximate to 6.0%) and good in vivo performance. Ultrabright PbS/CdS core/shell quantum dots (QDs) with dense polymer coating are used to visualize cancer-invaded sentinel LNs in the NIR-IIb (>1500 nm) window. Compared to clinically used indocyanine green, the QDs show superior brightness and photostability (no obvious bleaching even after continuous laser irradiation for 5 h); thus, only a picomolar dose is required for sentinel LNs detection. This combination of dual-NIR-II image-guided surgery can be performed under bright light, adding to its convenience and appeal in clinical use.

引用

页数：10

共 57 条

[1] A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging [J].

Antaris, Alexander L. ;

Chen, Hao ;

Diao, Shuo ;

Ma, Zhuoran ;

Zhang, Zhe ;

Zhu, Shoujun ;

Wang, Joy ;

Lozano, Alexander X. ;

Fan, Quli ;

Chew, Leila ;

Zhu, Mark ;

Cheng, Kai ;

Hong, Xuechuan ;

Dai, Hongjie ;

Cheng, Zhen .

NATURE COMMUNICATIONS, 2017, 8

[2] Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer [J].

Baklaushev, V. P. ;

Kilpelainen, A. ;

Petkov, S. ;

Abakumov, M. A. ;

Grinenko, N. F. ;

Yusubalieva, G. M. ;

Latanova, A. A. ;

Gubskiy, I. L. ;

Zabozlaev, F. G. ;

Starodubova, E. S. ;

Abakumova, T. O. ;

Isaguliants, M. G. ;

Chekhonin, V. P. .

SCIENTIFIC REPORTS, 2017, 7

[3] Next-generation in vivo optical imaging with short-wave infrared quantum dots [J].

Bruns, Oliver T. ;

Bischof, Thomas S. ;

Harris, Daniel K. ;

Franke, Daniel ;

Shi, Yanxiang ;

Riedemann, Lars ;

Bartelt, Alexander ;

Jaworski, Frank B. ;

Carr, Jessica A. ;

Rowlands, Christopher J. ;

Wilson, Mark W. B. ;

Chen, Ou ;

Wei, He ;

Hwang, Gyu Weon ;

Montana, Daniel M. ;

Coropceanu, Igor ;

Achorn, Odin B. ;

Kloepper, Jonas ;

Heeren, Joerg ;

So, Peter T. C. ;

Fukumura, Dai ;

Jensen, Klavs F. ;

Jain, Rakesh K. ;

Bawendi, Moungi G. .

NATURE BIOMEDICAL ENGINEERING, 2017, 1 (04)

[4] Optical nano-agents in the second near-infrared window for biomedical applications [J].

Cai, Yu ;

Wei, Zheng ;

Song, Chuanhui ;

Tang, Chuanchao ;

Han, Wei ;

Dong, Xiaochen .

CHEMICAL SOCIETY REVIEWS, 2019, 48 (01) :22-37

[5] Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green [J].

Carr, Jessica A. ;

Franke, Daniel ;

Caram, Justin R. ;

Perkinson, Collin F. ;

Saif, Mari ;

Askoxylakis, Vasileios ;

Datta, Meenal ;

Fukumura, Dai ;

Jain, Rakesh K. ;

Bawendi, Moungi G. ;

Bruns, Oliver T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (17) :4465-4470

[6] Renal clearance of quantum dots [J].

Choi, Hak Soo ;

Liu, Wenhao ;

Misra, Preeti ;

Tanaka, Eiichi ;

Zimmer, John P. ;

Ipe, Binil Itty ;

Bawendi, Moungi G. ;

Frangioni, John V. .

NATURE BIOTECHNOLOGY, 2007, 25 (10) :1165-1170

[7] Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging [J].

Cosco, Emily D. ;

Caram, Justin R. ;

Bruns, Oliver T. ;

Franke, Daniel ;

Day, Rachael A. ;

Farr, Erik P. ;

Bawendi, Moungi G. ;

Sletten, Ellen M. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (42) :13126-13129

[8] PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery [J].

Derks, Yvonne H. W. ;

Lowik, Dennis W. P. M. ;

Sedelaar, J. P. Michiel ;

Gotthardt, Martin ;

Boerman, Otto C. ;

Rijpkema, Mark ;

Lutje, Susanne ;

Heskamp, Sandra .

THERANOSTICS, 2019, 9 (23) :6824-6839

[9] Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging [J].

Ding, Feng ;

Zhan, Yibei ;

Lu, Xiaoju ;

Sun, Yao .

CHEMICAL SCIENCE, 2018, 9 (19) :4370-4380

[10]

Duan B., 2018, ADV MATER, V30

← 1 2 3 4 5 6 →