Platelet-Rich Plasma: A Promising Product for Treatment of Peripheral Nerve Regeneration After Nerve Injury

被引：102

作者：

Yu, WenJun ^{[1
]}

Wang, Jian ^{[2
]}

Yin, Jun ^{[1
]}

机构：

[1] Shantou Univ, Coll Med, Affiliated Hosp 2, Div Hematol, Shantou 515041, Guangdong, Peoples R China

[2] Shantou Univ, Coll Med, Affiliated Hosp 2, Dept Lab Med, Shantou 515041, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2011年 / 121卷 / 04期

关键词：

Growth factor; nerve regeneration; platelet-rich plasma; Schwann cells; FIBROBLAST-GROWTH-FACTOR; RAT SCIATIC-NERVE; NEUROTROPHIC FACTORS; SIGNALING PATHWAYS; FIBRIN SEALANT; FACTOR-BETA; IN-VIVO; REPAIR; CELLS; MODEL;

D O I：

10.3109/00207454.2010.544432

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nerve regeneration includes regrowth of injured axons as well as myelination, restoration of synaptic connections and recovery of physiological functions. Platelet-rich plasma (PRP) is prepared from the patient's own blood and contains growth factors that influence wound healing and used in various surgical fields including oral and maxillofacial surgery. When platelets are activated either ex vivo or in vivo, growth factors and proteins were released from platelets' alpha granules. Recent studies proved that PRP could promote regeneration of injured peripheral nerve. This review focuses on current trials using PRP to promote nerve regeneration and repairment, and proposes potential clinical application of PRP for nerve injury in the future.

引用

页码：176 / 180

页数：5

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