Histone H3K4 methylation keeps centromeres open for business

被引：11
作者：
Stimpson, Keitlin M. [1 ,2 ]
Sullivan, Beth A. [1 ,2 ]
机构：
[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27706 USA
[2] Duke Univ, Duke Inst Genome Sci & Policy, Durham, NC USA
来源：
EMBO JOURNAL | 2011年 / 30卷 / 02期
关键词：
CHROMATIN; KINETOCHORE; RNAS;
D O I：
10.1038/emboj.2010.339
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic centromeres are composed of a combination of nucleosomes containing the histone H3 variant CENP-A and canonical H3 di-methylated at lysine 4 (H3K4me2). Many questions exist over the functional importance of H3K4me2 nucleosomes within the centromere region. In this issue of The EMBO Journal, Bergmann et al (2011) reveal a role for H3K4me2 and transcription in CENP-A maintenance. They also extend the profile of centromeric histone modifications to include H3K36 methylation, typically found at transcribed regions of the genome.
引用
收藏
页码：233 / 234
页数：2
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