Complete genome sequence of Streptomyces lividans TK24

被引：72

作者：

Rueckert, Christian ^{[1
]}

Albersmeier, Andreas ^{[1
]}

Busche, Tobias ^{[1
]}

Jaenicke, Sebastian ^{[1
]}

Winkler, Anika ^{[1
]}

Friojonsson, Olafur H. ^{[2
]}

Hreggviosson, Guomundur Oli ^{[2
]}

Lambert, Christophe ^{[3
]}

Badcock, Daniel ^{[4
]}

Bernaerts, Kristel ^{[5
]}

Anne, Jozef ^{[6
]}

Economou, Anastassios ^{[6
,7
,8
]}

Kalinowski, Joern ^{[1
]}

机构：

[1] Univ Bielefeld, Ctr Biotechnol CeBiTec, D-33615 Bielefeld, Germany

[2] Matis, IS-113 Reykjavik, Iceland

[3] BioXpr SA, B-5000 Namur, Belgium

[4] GlaxoSmithKline, Cambridge CB4 0WG, England

[5] Katholieke Univ Leuven, Dept Chem Engn, Chem & Biochem Proc Technol & Control Sect BioTeC, Leuven, Belgium

[6] Katholieke Univ Leuven, Rega Inst Med Res, Lab Mol Bacteriol, Leuven, Belgium

[7] Univ Crete, Inst Mol Biol & Biotechnol FoRTH, Iraklion, Crete, Greece

[8] Univ Crete, Dept Biol, Iraklion, Crete, Greece

来源：

JOURNAL OF BIOTECHNOLOGY | 2015年 / 199卷

关键词：

Streptomyces; Model organism; Genome sequence; Heterologous protein expression; CORYNEBACTERIUM-GLUTAMICUM; HETEROLOGOUS EXPRESSION; SYSTEM; ANNOTATION; GENE;

D O I：

10.1016/j.jbiotec.2015.02.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces lividans TK24 is the standard host for the heterologous expression of a number of different proteins and antibiotic-synthesizing enzymes. As such, it is often used as an experimental microbial cell factory for the production of secreted heterologous proteins including human cytokines and industrial enzymes, and of several antibiotics. It accepts methylated DNA and is an ideal Streptomyces cloning system. Here, we report the complete genome sequence of S. lividans TK24 that includes a plasmid-less genome of 8.345 Mbp (72.24% G + C content). (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：21 / 22

页数：2

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